SegwayPD: The Effect of Sensory-augmented Postural Training Using Segway on Motor and Cognitive Function in Individuals With Parkinson's Disease

NCT05982730 | Recruiting

• 1 other identifier: 46179; STU-2023-0066
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the safety and efficacy of postural training emphasized on the integration of multiple sensory information into motor control in individuals with PD. This project is a proof-of-concept study to assess the effectiveness of postural training using Segway, which serves a platform to provide augmented and continuous proprioceptive and visuospatial information during postural training.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• Change from baseline postural sway at week 3

  The midpoint between the tip of left and right calcaneus bones is considered as the origin of the reference system of the center of pressure (CoP). The CoP displacement along lateral and anterior-posterior axes are measured. The overall size of postural sways will be estimated from the ellipse area conveying 85% of the total CoP samples. The postural sway obtained from 2 assessments during week 1 will be averaged and used as baseline value. The postural sway obtained at week 3 is used to analyze the change from baseline due to training intervention (week 2).

  Week 1 (2 assessments), Week 3 (1assessment)

Secondary Outcomes (3)

• Feasibility of Segway training

  Week 3 (1 assessment)

• Change from baseline gait spatiotemporal parameters at week 3

  Week 1 (2 assessments), Week 3 (1assessment)

• Change from baseline EEG spectral ratio at week 3

  Week 1 (2 assessments), Week 3 (1assessment)

Study Arms (1)

PD - individuals with Parkinson Disease, either male or female

EXPERIMENTAL

Individuals, aged 50-85, with a clinical diagnosis of idiopathic Parkinson Disease, either male or female, with moderate disease stage presenting balance alterations (Hoehn or Yahr stage III)

Behavioral: Sensory-Augmented Postural Training

Interventions

Sensory-Augmented Postural Training BEHAVIORAL

To examine the safety and efficacy of postural training emphasized on the integration of multiple sensory information into motor control and to assess the effectiveness of postural training using Segway

PD - individuals with Parkinson Disease, either male or female

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• a clinical diagnosis of idiopathic PD with moderate disease stage presenting balance alterations (Hoehn and Yahr stage III)
• being stable on medication for at least 1 month
• the ability to stand and walk unsupported for 5 min both on and off medication
• age between 50 and 85

You may not qualify if:

• neurological disorders other than PD
• major unstable medical illnesses
• sensory or musculoskeletal disorders (e.g., diabetes, uncorrected visual problems, arthritis, severe hearing impairments) that will prohibit the ability to perform the assessment tests and receive training

Sponsors & Collaborators

• University of Texas Southwestern Medical Center: lead

Study Sites (1)

University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Yasin Dhaher, Ph.D.

  University of Texas Southwestern Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yu-Chen Chung, PT, Ph.D.

CONTACT

214-648-8838; yu-chen.chung@utsouthwestern.edu

Subaryani Soedirdjo, Ph.D.

CONTACT

subaryani.soedirdjo@utsouthwestern.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: July 6, 2023
• First Posted: August 9, 2023
• Study Start: November 8, 2023
• Primary Completion (Estimated): July 31, 2026
• Study Completion (Estimated): July 31, 2026
• Last Updated: August 13, 2025

Record last verified: 2025-08

Locations

US (1)