A Research Registry on Aggressive PitNETs

NCT05974696 | Recruiting

• 1 other identifier: 69HCL23_0026
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

To allow the identification of markers, it is necessary to extend research networks more widely to collect and properly explore aggressive pituitary tumours. The multidisciplinary consultation meeting (RCP), organised by the reference centre for rare diseases of the pituitary gland, dedicated to aggressive pituitary tumours and carcinomas (HYPOcare), which is unique in France and brings together national experts, currently makes it possible to orientate the management of patients with an aggressive pituitary tumour. With more than 80 patient files discussed since its inception, the patient cohort via the HYPOcare RCP is one of the largest both nationally and internationally. At present, this data source is only dedicated to the clinical management of the files without the possibility of carrying out research work

Conditions

Endocrine Tumor

Keywords

Endocrine Tumor; Reference centre; rare diseases; transcriptoms

Outcome Measures

Primary Outcomes (1)

• Characterisation of aggressiveness of pituitary tumours by tanscriptome analysis

  Molecular and transcriptomic signature of aggressiveness of pituitary tumours predictive of prognosis

  3 years

Study Arms (1)

Patients RECAPitNETT

All adult subjects with pituitary tumours whose file is presented to the national HYPOcare RCP. There is only one group.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult subjects with pituitary tumours whose file is presented to the national HYPOcare RCP. There is only one group.

You may qualify if:

• Patients with a diagnosis of pituitary tumour
• Patients whose file has been presented to the national HYPOcare RCP

You may not qualify if:

• Patients objecting to participating in this research

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hospices Civils de Lyon - Groupement Hospitalier Est

Lyon, 69003, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Anatomopathology samples collected and analysed as part of the routine care of the patient will be sent for centralised analysis to the Cochin Institute in Paris.

MeSH Terms

Conditions

Endocrine Gland Neoplasms; Rare Diseases

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Endocrine System Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2023
• First Posted: August 3, 2023
• Study Start: June 15, 2023
• Primary Completion (Estimated): June 15, 2029
• Study Completion (Estimated): June 15, 2029
• Last Updated: August 8, 2023

Record last verified: 2023-07

Locations

FR (1)