The Atherogenic Index of Plasma（AIP） in Patients With Atrial Fibrillation

NCT05973474 | Unknown

• 1 other identifier: SYSKY-2023-634-01
• Study Type: observational
• Target: 5,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to learn about The Atherogenic Index of Plasma(AIP) in patients with atrial fibrillation(AF). The main questions it aims to answer are: (1)To investigate the correlation between AIP and the occurrence rate of AF. (2) To investigate the correlation between AIP and the occurrence rate of cardiovascular outcome events (MACE events, heart failure, embolism events) in patients with AF. Patients's clinical data including medical history, laboratory tests, and imageological examination will be collected and further analysed.

Conditions

Atrium; Fibrillation; Lipid Metabolism Disorders; Cardiovascular Diseases; Event, Cardiac

Outcome Measures

Primary Outcomes (1)

• atrial fibrillation (AF)

  AF diagnoses were ascertained by 3 different sources in our study: ECGs performed at study visits, hospital discharge codes, and death certificates. All ECGs automatically coded as AF were visually checked by a trained cardiologist to confirm AF diagnosis.

  10 years

Secondary Outcomes (2)

• major adverse cardiovascular events (MACEs)

  10 years

• heart failure

  10 years

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients diagnosed with AF during hospitalization in our hospital.

You may qualify if:

• Atrial fibrillation was detected by electrocardiogram or 24-hour holter or portable electrocardiogram monitor;
• age ≥18 years old;
• "low-intermediate" risk group of AF cardioembolic stroke: male patients with CHA2DS2-VASc score 0-1 or female patients with CHA2DS2-VASc score 1-2

You may not qualify if:

• patients with rheumatic heart disease, congenital heart disease, cardiomyopathy, hematological diseases, severe hepatic and renal insufficiency and connective tissue diseases;
• Echocardiography showed valvular heart disease;
• patients with transient atrial fibrillation secondary to reversible causes: hyperthyroidism, acute pulmonary embolism, recent surgery, acute myocardial infarction, etc.
• severe carotid artery stenosis and intracranial artery stenosis;
• AF patients with recent major surgery.
• patients with serious lack of clinical data.

Sponsors & Collaborators

• Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University: lead

MeSH Terms

Conditions

Atrial Fibrillation; Lipid Metabolism Disorders; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate chief physician

Study Record Dates

• First Submitted: July 25, 2023
• First Posted: August 3, 2023
• Study Start: July 30, 2023
• Primary Completion: March 1, 2024
• Study Completion: July 1, 2024
• Last Updated: August 3, 2023

Record last verified: 2023-07