Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center

NCT05972408 | Completed

• 1 other identifier: MD.21.02.426
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based stones among Patients with Renal Calcular Disease in Mansoura Urology and Nephrology Center

Conditions

Renal Calculi

Keywords

renal calculi, Renal Ca oxalate stones, VDR gene

Outcome Measures

Primary Outcomes (2)

• prevalence of Ca-based renal stones

  Prevalence of Ca stones among patients with kidney stone disease admitted in Mansoura UNC throughout the study duration as assessed by infrared spectroscopic stone analysis

  two years

• Genetic background of Ca based renal stones

  Identification of metabolic derangement and genomic alterations in patients with renal Ca stones (CASR, and VDR genes)

  two years

Secondary Outcomes (1)

• Stone recurrence

  two years

Interventions

percutaneous nephrlolithotomy PROCEDURE

Endoscopic removal of renal stones

VDR gene, CASR gene GENETIC

checking possible mutations of VDR and CASR genes

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients with unilateral or bilateral renal stones (de novo or recurrent) who were candidates for endoscopic or surgical intervention

You may qualify if:

• All patients with unilateral or bilateral renal stones (de novo or recurrent) who were candidates for endoscopic or surgical intervention were included. Metabolic workup was done for selected patients with radio-opaque stones, while genetic testing was done for those with dominant Ca composition proven by postoperative stone analysis. Thirty healthy individuals with no urologic abnormalities were involved as control cases. Patients with renal calculi for whom metabolic and genetic testing were performed are designated "α" cases.

You may not qualify if:

• For metabolic and genetic testing, patients with a well-known lesion precipitating stone disease were excluded e.g. ureteric stricture, ureteropelvic or ureterovesical junction obstruction, urinary diversion, history of ureterovesical re-implantation as well as patients with non-Ca stones by post-operative stone analysis

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura University

Al Mansurah, Outside U.S./Canada, 35561, Egypt

Location

Related Publications (1)

• Wang C, Lu J, Lang Y, Liu T, Wang X, Zhao X, Shao L. Two novel AGXT mutations identified in primary hyperoxaluria type-1 and distinct morphological and structural difference in kidney stones. Sci Rep. 2016 Sep 20;6:33652. doi: 10.1038/srep33652.

  PMID: 27644547 BACKGROUND

MeSH Terms

Conditions

Kidney Calculi

Interventions

Receptors, Calcitriol; Receptors, Calcium-Sensing

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Receptors, Cytoplasmic and Nuclear; Proteins; Amino Acids, Peptides, and Proteins; Receptors, G-Protein-Coupled; Receptors, Cell Surface; Membrane Proteins

Study Design

• Study Type: observational
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: July 25, 2023
• First Posted: August 2, 2023
• Study Start: March 21, 2021
• Primary Completion: September 21, 2023
• Study Completion: January 19, 2024
• Last Updated: June 10, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)