Correlation of Glucose and Lipid Metabolism Levels With Vitiligo

NCT05968235 | Completed

• 1 other identifier: XJPF-LCY-V202307
• Study Type: observational
• Target: 963
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to compare serum glucose and lipid metabolism levels between health volunteers and vitiligo patients. The main question it aims to answer is whether vitiligo is related to glucose and lipid metabolism disorders. Participants will complete a vitiligo questionnaire and test serum levels of indicators related to glucose and lipid metabolism. Researchers will compare vitiligo patients with healthy volunteers to see if there is a correlation between vitiligo and disorders of glucose and lipid metabolism.

Conditions

Metabolism Disorder, Glucose; Metabolism Disorder, Lipid; Vitiligo

Keywords

Vitiligo; Glucose; Lipid

Outcome Measures

Primary Outcomes (2)

• Demographic and epidemiological information of the study subjects

  Detailed records of demographic information (age, gender, occupation, education degree, life history, et al.), clinical information of vitiligo (age at onset, duration, severity, type, treatment, complication, et al.) and physical examination index (height, weight, blood pressure, heart rate).

  2020.02.01-2023.03.25

• Serum glucose and lipid metabolism levels of the study subjects

  Detection of fasting blood glucose, glycosylated hemoglobin, triglycerides, total cholesterol, high-density lipoproteins, and low-density lipoproteins in peripheral blood of study subjects.

  2020.02.01-2023.03.25

Study Arms (2)

Vitiligo

Patients diagnosed with vitiligo

Other: Collecting blood samples

Healthy

Healthy volunteers with sex- and age-matched with vitiligo patients

Other: Collecting blood samples

Interventions

Collecting blood samples OTHER

Peripheral blood was collected from the study subjects and blood glucose, glycosylated hemoglobin, triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were measured in the peripheral blood.

Healthy; Vitiligo

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

We recruited patients with clinically diagnosed vitiligo and age- and sex-matched healthy volunteers.

You may qualify if:

• Patients diagnosed as vitiligo by a dermatologist based on a combination of clinical manifestations (milky white or porcelain white patches), Wood's Lamp test results (bright white fluorescence), and histopathologic test results (reduction or disappearance of epidermal melanocytes in the white patches);
• Male or female subjects, age between 18 and 60 years old;
• Stable vital signs;
• Study subjects voluntarily signed an informed consent form.

You may not qualify if:

• Subjects who have been systematically using glucocorticoids, immunosuppressants, etc. that affect glycolipid levels due to a combination of diseases other than metabolic diseases in the last 3 months shall be asked and determined by a clinician;
• Women who are pregnant or breastfeeding shall be asked and determined by a clinician;
• Subjects who suffer from psychiatric disorders, etc. and who are not capable of cooperating with the follow-up study shall be asked and determined by a clinician.

Sponsors & Collaborators

• Xijing Hospital: lead

Study Sites (1)

Xijing Hospital

Xi'an, Shaanxi, 710032, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples of vitiligo patients and healthy volunteers

MeSH Terms

Conditions

Glucose Metabolism Disorders; Lipid Metabolism Disorders; Vitiligo

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases; Hypopigmentation; Pigmentation Disorders; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Chunying Li

  Air Force Military Medical University, China

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice Chief

Study Record Dates

• First Submitted: July 21, 2023
• First Posted: August 1, 2023
• Study Start: February 1, 2020
• Primary Completion: March 25, 2022
• Study Completion: March 25, 2023
• Last Updated: August 1, 2023

Record last verified: 2023-07

Locations

CN (1)