Functional MRI to Assess Brain Damage in Cardiac Arrest Patients

NCT05966389 | Completed DMC

• 1 other identifier: 2023-6-21-8
• Study Type: observational
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center, observational study. Patients after successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management. After successful return of spontaneous circulation (ROSC) for 72h and hemodynamics remained stable for 24h, the post-resuscitated patients underwent functional magnetic resonance imaging (fMRI) examination. During the examination, the supervising physician accompanied the patient and monitored the patient's vital signs using a magnetic resonance monitoring system (Siemens Healthcare Prism, Germany). Patients who are on ventilators are mechanically ventilated using a magnetic ventilator (HAMILTON-MRI, USA). In additional to conventional sequences, fMRI is performed for diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) and blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI). These MRI sequences allow quantitative assessment of the patients' cerebral microcirculation, blood-brain barrier, and cerebral oxygenation status. Patients will be followed up for neurologic prognosis according to the Modified Rankin Scale (mRS) at 6 months after disease onset.

Conditions

Cardiac Arrest; Brain Injuries

Keywords

Cardiac arrest; functional Magnetic Resonance Imaging; cerebral microcirculation; blood-brain barrier; cerebral oxygenation

Outcome Measures

Primary Outcomes (1)

• Neurologic prognosis

  Patients will be followed up for neurologic prognosis according to the Modified Rankin Scale (mRS) at 6 months after disease onset.

  6 months

Interventions

No interventions OTHER

No interventions

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients after successful cardiopulmonary resuscitation (CPR) were transferred to the emergency intensive care unit for further standardized management.

You may qualify if:

• age ≥18 years.
• sustained hemodynamic stability for ≥24h.
• the patients were unconscious and not able to obey verbal commands.
• Advanced life support and target temperature management within 6 hours of return of spontaneous circulation (ROSC).

You may not qualify if:

• Patients with hemodynamic instability.
• Patients who could not complete cranial MRI examination for special reasons.
• Patients during pregnancy.
• Patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
• Patients whose family members did not agree to be enrolled.

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

Beijing chaoyang hospital

Beijing, Beijing Municipality, 100020, China

Location

Related Publications (1)

• Shao R, Wang T, Hang C, An L, Wang X, Zhang L, Yu J, Shan Z, Yang Q, Tang Z. Alteration in early resting-state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study. Crit Care. 2024 Aug 2;28(1):260. doi: 10.1186/s13054-024-05045-4.

  PMID: 39095884 DERIVED

MeSH Terms

Conditions

Heart Arrest; Brain Injuries

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 18, 2023
• First Posted: July 28, 2023
• Study Start: January 1, 2021
• Primary Completion: January 31, 2024
• Study Completion: January 31, 2024
• Last Updated: October 8, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: starting 6 months after publication
• Access Criteria: The de-identified survey data will be made available for research purposes by contacting the corresponding authors

Locations

CN (1)