Mortality and Morbidity Associated With New Onset Acute Kidney Injury in Critically Ill COVID-19 Infection Patients

NCT05964088 | Completed

• 1 other identifier: 22-18
• Study Type: observational
• Target: 267
• Locations: 1 country
• Sites: 1

Brief Summary

This study explored the incidence of morbidity and mortality associated with AKI in critically ill adult patients infected with COVID-19. There are two groups for comparison. Group1. patients were directly admitted to the intensive care unit (ICU) from the emergency department (ED) Group 2. patients were initially managed on the medical floor and later transferred to the ICU for worsening respiratory status. The investigating team evaluated the correlation of inflammatory markers and common risk factors such as obesity, diabetes, hypertension and ethnicity to the development of AKI in the target population. The primary outcome is mortality participants will received their regular healthcare in a medical setting

Conditions

Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• Mortality

  mortality at hospital discharge

  from admission until death from any cause, whichever comes first, assessed up to three months

Study Arms (2)

Group1

These critically ill patients were directly admitted to the intensive care unit from the emergency department

Group 2

These critically ill patients were were initially managed on the medical floor and later transferred to the intensive care unit for worsening respiratory status

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a two-year retrospective study of critically ill adult patients infected with COVID-19 that were admitted to the intensive care unit on ventilatory support. Patients included in this study were admitted to Arrowhead Regional Medical Center (ARMC) from March 1, 2020 to February 12, 2022.

You may qualify if:

• positive for SARS-CoV-2 on a real-time polymerase chain reaction test (RT-PCR) upon admission to the hospital

You may not qualify if:

• chronic kidney disease end stage renal disease

Sponsors & Collaborators

• Arrowhead Regional Medical Center: lead

Study Sites (1)

Arrowhead Regional Medical Center

Colton, California, 92324, United States

Location

Related Publications (1)

• Fischer N, Miao X, Weck D, Matalon J, Neeki CC, Pennington T, Dong F, Arabian S, Neeki MM. Mortality and morbidity associated with new onset acute kidney injury in critically ill COVID-19 infection patients. Int J Emerg Med. 2024 Jul 29;17(1):97. doi: 10.1186/s12245-024-00666-6.

  PMID: 39075369 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Michael M Neeki, DO

  Arrowhead Regional Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending Physician

Study Record Dates

• First Submitted: July 24, 2023
• First Posted: July 27, 2023
• Study Start: March 1, 2020
• Primary Completion: February 12, 2022
• Study Completion: February 12, 2022
• Last Updated: July 27, 2023

Record last verified: 2023-07

Locations

US (1)