NCT05948202

Brief Summary

This project tests the feasibility and preliminary proof of concept for a mindfulness-enhanced adaptation of Pivotal Response Treatment on parenting stress and child communication, using a randomized controlled design.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2017

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 10, 2017

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 4, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 4, 2020

Completed
3.3 years until next milestone

First Submitted

Initial submission to the registry

June 1, 2023

Completed
2 months until next milestone

First Posted

Study publicly available on registry

July 17, 2023

Completed
Last Updated

July 17, 2023

Status Verified

July 1, 2023

Enrollment Period

2.8 years

First QC Date

June 1, 2023

Last Update Submit

July 7, 2023

Conditions

Outcome Measures

Primary Outcomes (19)

  • Therapist fidelity observation

    observation at 30-second intervals; number out of 10 pivotal response therapy components observed for each 30-second interval of the recording and then averaged over the length of the recording (which were 5-10 minutes long)

    weekly, from start of treatment through 12 weeks

  • Child utterances - observation

    level or amount of child utterances during a structured laboratory task observation

    pre-treatment at intake

  • Child utterances - observation

    level or amount of child utterances during a structured laboratory task observation

    mid-treatment, at 6 weeks from start of treatment

  • Child utterances - observation

    level or amount of child utterances during a structured laboratory task observation

    weekly, from start of treatment through 12 weeks

  • Child utterances - observation

    level or amount of child utterances during a structured laboratory task observation

    post-treatment, at 12 weeks from start of treatment

  • Child utterances - observation

    level or amount of child utterances during a structured laboratory task observation

    follow-up, at 3 months after the last treatment session

  • Parent fidelity observation

    observation at 30-second intervals; number out of 10 pivotal response therapy components observed for each 30-second interval of the recording and then averaged over the length of the recording (which were 5-10 minutes long)

    weekly, from start of treatment through 12 weeks

  • Parenting Stress Index, 4th edition

    level of parent-reported stress;

    pre-treatment at intake

  • Parenting Stress Index, 4th edition

    level of parent-reported stress

    mid-treatment, at 6 weeks from start of treatment

  • Parenting Stress Index, 4th edition

    level of parent-reported stress

    post-treatment, at 12 weeks from start of treatment

  • Parenting Stress Index, 4th edition

    level of parent-reported stress

    follow-up, at 3 months after last treatment session

  • Autism Parenting Stress Index

    level of parent-reported stress specific for parents of young autistic children

    pre-treatment at intake

  • Autism Parenting Stress Index

    level of parent-reported stress specific for parents of young autistic children

    mid-treatment, at 6 weeks from start of treatment

  • Autism Parenting Stress Index

    level of parent-reported stress specific for parents of young autistic children

    post-treatment, at 12 weeks from start of treatment

  • Autism Parenting Stress Index

    level of parent-reported stress specific for parents of young autistic children

    follow-up, at 3 months after last treatment session

  • Subjective Units of Parenting Stress Scale

    level of parent-reported stress immediately following the structured lab observation, with 0 signifying no stress and 100 signifying extreme stress

    pre-treatment at intake

  • Subjective Units of Parenting Stress Scale

    level of parent-reported stress immediately following the structured lab observation, with 0 signifying no stress and 100 signifying extreme stress

    mid-treatment, at 6 weeks from start of treatment

  • Subjective Units of Parenting Stress Scale

    level of parent-reported stress immediately following the structured lab observation, with 0 signifying no stress and 100 signifying extreme stress

    post-treatment, at 12 weeks from start of treatment

  • Subjective Units of Parenting Stress Scale

    level of parent-reported stress immediately following the structured lab observation

    follow-up, at 3 months after last treatment session

Secondary Outcomes (16)

  • Parent Feelings Questionnaire

    pre-treatment, at intake

  • Parent Feelings Questionnaire

    mid-treatment, at 6 weeks from start of treatment

  • Parent Feelings Questionnaire

    post-treatment, at 12 weeks from start of treatment

  • Parent Feelings Questionnaire

    follow-up, at 3 months after last treatment session

  • Positive and Negative Affect Schedule

    pre-treatment, at intake

  • +11 more secondary outcomes

Other Outcomes (1)

  • Parent Treatment Satisfaction Questionnaire

    post-treatment, at 12 weeks from start of treatment

Study Arms (2)

mPRT

EXPERIMENTAL

mindfulness-enhanced Pivotal Response Treatment: group pivotal response training for parents that is supplemented with mindfulness strategies

Behavioral: Pivotal Response Treatment

pPRT

ACTIVE COMPARATOR

psychoeducation-enhanced Pivotal Response Treatment: group pivotal response training for parents that is supplemented with psychoeducation about stress and stress reduction

Behavioral: Pivotal Response Treatment

Interventions

Group-based parent training to teach parents behavioral strategies based on principles of learning to motivate their child.

mPRTpPRT

Eligibility Criteria

Age18 Months - 6 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • For children: minimally verbal or nonverbal, 1.5 to 6 years old, current or suspected autism spectrum disorder diagnosis, demonstrated ability to make meaningful vocalizations
  • For parents: willingness to attend group treatment sessions, record weekly videos, and share videos in a group setting

You may not qualify if:

  • For children, no active medical problems (e.g., unstable seizure disorders)
  • For parents, no severe mental health problems (e.g., suicidal intent, psychosis)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Virginia Tech Autism Clinic

Blacksburg, Virginia, 24060, United States

Location

Related Publications (2)

  • Hayes SA, Watson SL. The impact of parenting stress: a meta-analysis of studies comparing the experience of parenting stress in parents of children with and without autism spectrum disorder. J Autism Dev Disord. 2013 Mar;43(3):629-42. doi: 10.1007/s10803-012-1604-y.

    PMID: 22790429BACKGROUND
  • Osborne LA, McHugh L, Saunders J, Reed P. Parenting stress reduces the effectiveness of early teaching interventions for autistic spectrum disorders. J Autism Dev Disord. 2008 Jul;38(6):1092-103. doi: 10.1007/s10803-007-0497-7. Epub 2007 Nov 20.

    PMID: 18027079BACKGROUND

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, PervasiveNeurodevelopmental DisordersMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: randomized controlled trial
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 1, 2023

First Posted

July 17, 2023

Study Start

April 10, 2017

Primary Completion

February 4, 2020

Study Completion

February 4, 2020

Last Updated

July 17, 2023

Record last verified: 2023-07

Data Sharing

IPD Sharing
Will share

The de-identified data are shared with other members of the research team.

Shared Documents
STUDY PROTOCOL, SAP

Locations