Safety and Tolerance of Increased Doses of SHR-2106 Injection in Healthy Subjects

NCT05948059 | Completed Phase 1

• 1 other identifier: SHR-2106-101
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized, double-blind, placebo-controlled phase I clinical study with the primary objective of evaluating the safety and tolerability of SHR-2106 in healthy subjects after a single intravenous or subcutaneous administration.

Conditions

Kidney Transplantation

Outcome Measures

Primary Outcomes (1)

• Assess the incidence and severity of adverse events in healthy subjects after single dose of SHR-2106 injection

  About 6 months from the first medication to the evaluation

Secondary Outcomes (7)

• Assess the concentration of SHR-2106 in plasma

  About 6 months after the first dose

• Evaluation of AUC0-t of SHR-2106 in plasma

  About 6 months after the first dose

• Evaluation of AUC0-∞ of SHR-2106 in plasma

  About 6 months after the first dose

• Evaluation of Tmax of SHR-2106 in plasma

  About 6 months after the first dose

• Evaluation of Cmax of SHR-2106 in plasma

  About 6 months after the first dose

Study Arms (2)

Part 1: SHR-2106 injection or placebo single dose, iv

EXPERIMENTAL

Drug: SHR-2106 injection or placebo

Part 2: SHR-2106 injection or placebo single dose, sc

EXPERIMENTAL

Drug: SHR-2106 injection or placebo

Interventions

SHR-2106 injection or placebo DRUG

starting dose from 50 mg

Part 1: SHR-2106 injection or placebo single dose, iv

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Obtain informed consent prior to the commencement of any activities related to the trial, have a full understanding of the purpose and significance of the trial, and be willing to comply with the trial protocol;
• Age 18 \~ 55 years old (including boundary value), male or female;
• Male weight ≥ 50 kg, female weight ≥ 45 kg, body mass index (BMI) = weight (kg) / height 2 (m2), BMI in the range of 19 \~ 28 kg/m2 (including boundary value);
• Random pre-physical examination, vital signs, laboratory tests (blood routine, urine routine, blood biochemistry, coagulation function), thyroid function, chest radiograph, 12-lead ECG results are normal or abnormal and have no clinical significance;
• Subjects and their partners who have no fertility plan and voluntarily take highly effective contraception during the study period to the last follow-up of the trial (the last follow-up time between dose groups is shown in Table 9), 6 months (female subjects receiving SHR-2106) or 3 months (male subjects receiving SHR-2106) and voluntarily take highly effective contraception (see Annex 1 of the protocol for specific contraceptive measures), female subjects must have a negative serum pregnancy test and be non-lactating.

You may not qualify if:

• The subject's medical history, symptoms and examination results at the time of screening suggest active tuberculosis or latent tuberculosis. All participants will be screened for TB status by γ interferon gamma release assay (IGRA) and chest radiograph (x-ray). Participants who underwent IGRA and x-ray examination within 1 month prior to screening may, at the discretion of the investigator, not repeat IGRA and x-ray at screening;
• History of severe cardiovascular, liver, kidney, digestive tract, psychiatric, hematology, metabolic and other diseases (within 5 years);
• Those who have serious infection, severe trauma or major surgery within 6 months before screening or administration; those who plan to undergo surgery during the trial;
• Those who have chronic infection or recurrent infection within 12 months before screening and need treatment;
• Those who donated blood or lost a total of ≥200 mL within 1 month before screening or administration, or ≥ 400 mL of blood donation or blood loss within 3 months before administration, or who received blood transfusion within 2 months;
• Those who have a history of allergies to two or more foods and drugs; or a known history of allergy to the study drug or any component of the study drug (see Annex 2 of the protocol for injectable ingredients);
• History of tobacco addiction within 3 months before screening, defined as: an average of more than 5 cigarettes smoked per day; or those who are unable to comply with the no-smoking requirements during the study;
• Alcoholics within 3 months before screening (1 day intake of alcohol more than 15 g for women, more than 25 g for men \[5 g of alcohol is equivalent to 150 mL of beer, 50 mL of wine or about 17 mL of low-alcohol liquor\], more than 2 times a week) or positive alcohol breath test at baseline;
• Systolic blood pressure (SBP) before screening or administration: SBP ≥ 140 mmHg or \< 90 mmHg; diastolic blood pressure (DBP) :D BP≥ 90 mmHg or \< 50 mmHg;
• Glutaminase (AST) or alanine aminotransferase (ALT) at screening≥ 2 times the upper limit of normal range (ULN), or total bilirubin ≥ 1.5 times ULN
• Those with abnormal coagulation function and clinically significant, or those who have bleeding tendency or are receiving thrombolysis or anticoagulation therapy, or those who need to receive preventive anticoagulation therapy during the test
• Those at risk of thromboembolic events (such as history of thromboembolism, cardiovascular disease, diabetes, recurrent spontaneous miscarriage, dyslipidemia);
• Abnormal and clinically significant 12-lead ECG results before screening or administration (e.g., male QTcF\> 450 ms; QTcF for women \>470 ms);
• Those who are positive for urine drug screening during the screening period; or those with a history of substance abuse within the previous 2 years of screening;
• Those who are positive for infectious disease screening (including hepatitis B virus surface antigen, hepatitis C virus antibody, human immunodeficiency virus antibody, syphilis antibody) during the screening period;

Sponsors & Collaborators

• Guangdong Hengrui Pharmaceutical Co., Ltd: lead

Study Sites (1)

The third xiangya hospital of central south univercity

Changsha, Hunan, 410013, China

Location

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2023
• First Posted: July 17, 2023
• Study Start: July 11, 2023
• Primary Completion: May 10, 2024
• Study Completion: May 10, 2024
• Last Updated: June 10, 2026

Record last verified: 2026-06

Locations

CN (1)