The Frequency of Beef Allergy in Children With Cow Milk Allergy

NCT05943704 | Completed DMC

• 1 other identifier: FMASU MS322/2022
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to determine the frequency of allergy to beef meat in children with allergy to cow's milk by serum measurement. Also, the study aims to assess the sensitivity and specificity of beef IgE in relation to gold standardized of elimination challenge test and to assess effect of eating of cooked meat on symptoms of allergy in those proven to have either CMA alone +/- beef allergy (by serology).

Conditions

Cow Milk Allergy

Outcome Measures

Primary Outcomes (1)

• Children with Positive IgE for beef.

  6 months

Study Arms (1)

Children with cow milk allergy.

EXPERIMENTAL

Beef introduction for children proven to have cow milk protein allergy

Dietary Supplement: beef broth

Interventions

beef broth DIETARY_SUPPLEMENT

It indicates if the child has allergy of Beef or not.

Children with cow milk allergy.

Eligibility Criteria

• Age: 7 Months - 3 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Children from seven months to three years old newly diagnosed with cow milk allergy at Gastroenterology Unit and Allergy, Rheumatology and Immunology Unit.

You may not qualify if:

• Critically ill children.
• Patients diagnosed as immune deficiency.
• Patients receiving long term steroid therapy or anti-histaminic.
• Patients who had anaphylaxis or severe reactions from milk
• Patients with skin diseases which can mask skin reactions

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Faculty of Medicine, Ain Shams University

Cairo, 11566, Egypt

Location

Related Publications (10)

• Fiocchi A, Restani P, Riva E, Mirri GP, Santini I, Bernardo L, Galli CL. Heat treatment modifies the allergenicity of beef and bovine serum albumin. Allergy. 1998 Aug;53(8):798-802. doi: 10.1111/j.1398-9995.1998.tb03977.x.

  PMID: 9722230 BACKGROUND

• Gonzales-Gonzalez VA, Diaz AM, Fernandez K, Rivera MF. Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children. Allergy Asthma Clin Immunol. 2018 Jun 18;14:23. doi: 10.1186/s13223-018-0245-x. eCollection 2018.

  PMID: 29946340 BACKGROUND

• Espin Jaime B, Diaz Martin JJ, Blesa Baviera LC, Claver Monzon A, Hernandez Hernandez A, Garcia Burriel JI, Merida MJG, Pinto Fernandez C, Coronel Rodriguez C, Roman Riechmann E, Ribes Koninckx C. [Non-IgE-mediated cow's milk allergy: Consensus document of the Spanish Society of Paediatric Gastroenterology, Hepatology, and Nutrition (SEGHNP), the Spanish Association of Paediatric Primary Care (AEPAP), the Spanish Society of Extra-hospital Paediatrics and Primary Health Care (SEPEAP), and the Spanish Society of Paediatric ClinicaL Immunology, Allergy, and Asthma (SEICAP)]. An Pediatr (Engl Ed). 2019 Mar;90(3):193.e1-193.e11. doi: 10.1016/j.anpedi.2018.11.007. Epub 2019 Jan 19. Spanish.

  PMID: 30665859 BACKGROUND

• Martelli A, De Chiara A, Corvo M, Restani P, Fiocchi A. Beef allergy in children with cow's milk allergy; cow's milk allergy in children with beef allergy. Ann Allergy Asthma Immunol. 2002 Dec;89(6 Suppl 1):38-43. doi: 10.1016/s1081-1206(10)62121-7.

  PMID: 12487203 BACKGROUND

• Martorell A, Plaza AM, Bone J, Nevot S, Garcia Ara MC, Echeverria L, Alonso E, Garde J, Vila B, Alvaro M, Tauler E, Hernando V, Fernandez M. Cow's milk protein allergy. A multi-centre study: clinical and epidemiological aspects. Allergol Immunopathol (Madr). 2006 Mar-Apr;34(2):46-53. doi: 10.1157/13086746.

  PMID: 16606545 BACKGROUND

• Paschke A, Besler M. Stability of bovine allergens during food processing. Ann Allergy Asthma Immunol. 2002 Dec;89(6 Suppl 1):16-20. doi: 10.1016/s1081-1206(10)62117-5.

  PMID: 12487199 BACKGROUND

• Skypala IJ, Venter C, Meyer R, deJong NW, Fox AT, Groetch M, Oude Elberink JN, Sprikkelman A, Diamandi L, Vlieg-Boerstra BJ; Allergy-focussed Diet History Task Force of the European Academy of Allergy and Clinical Immunology. The development of a standardised diet history tool to support the diagnosis of food allergy. Clin Transl Allergy. 2015 Feb 19;5:7. doi: 10.1186/s13601-015-0050-2. eCollection 2015.

  PMID: 25741437 BACKGROUND

• Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Halken S, Poulsen L, van Ree R, Vlieg-Boerstra BJ, Sheikh A; EAACI Food Allergy and Anaphylaxis Guidelines Group. The diagnosis of food allergy: a systematic review and meta-analysis. Allergy. 2014 Jan;69(1):76-86. doi: 10.1111/all.12333. Epub 2013 Dec 14.

  PMID: 24329961 BACKGROUND

• Venter C, Brown T, Shah N, Walsh J, Fox AT. Diagnosis and management of non-IgE-mediated cow's milk allergy in infancy - a UK primary care practical guide. Clin Transl Allergy. 2013 Jul 8;3(1):23. doi: 10.1186/2045-7022-3-23.

  PMID: 23835522 BACKGROUND

• Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow's milk. J Allergy Clin Immunol. 1997 Mar;99(3):293-300. doi: 10.1016/s0091-6749(97)70045-9.

  PMID: 9058683 BACKGROUND

MeSH Terms

Conditions

Milk Hypersensitivity

Condition Hierarchy (Ancestors)

Food Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 6, 2023
• First Posted: July 13, 2023
• Study Start: September 15, 2023
• Primary Completion: May 30, 2024
• Study Completion: August 28, 2024
• Last Updated: May 7, 2025

Record last verified: 2025-04

Locations

EG (1)