Observational Study on "Functional Overlay" in Patients With Movement Disorders
Prevalence and Clinical Presentation of Functional Neurological Disorders in Patients With Movement Disorders - A Cross-sectional Study in the Movement Disorders Clinic of the Department of Neurology, Medical University of Graz
1 other identifier
observational
216
1 country
1
Brief Summary
The goal of this observational study is to learn about functional neurological disorders in patients with common non-functional movement disorders ("functional overlay"). The main questions it aims to answer are:
- What is the frequency of functional neurological disorders in patients with non-functional movement disorders (functional overlay)?
- What are the characteristics of functional neurological disorders in patients with non-functional movement disorders? Participants will be examined clinically and electrophysiologically, the examinations consist of:
- a neurological examination
- neuropsychological testing
- electrophysiological tremor diagnostic
- questionnaires about psychological, biological and social risk factors Researchers will compare patients with functional motor disorders to patients wit non-functional movement disorders to see if they differ from each other regarding the functional symptoms.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2023
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2023
CompletedFirst Submitted
Initial submission to the registry
July 5, 2023
CompletedFirst Posted
Study publicly available on registry
July 13, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2026
ExpectedSeptember 29, 2025
September 1, 2025
3 years
July 5, 2023
September 23, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Functional neurological symptoms
Diagnosed by positive signs for functional neurological symptoms, as assessed in the neurological examination
on average 30 minutes
Secondary Outcomes (21)
Duration of anamnesis
1 to 3 minutes
Tremor diagnostic
up to 20 minutes
Subjective quality of life
5 minutes
Subjective health
up to 10 minutes
Fatigue
up to 5 minutes
- +16 more secondary outcomes
Study Arms (6)
Parkinson Disease
Idiopathic Dystonia
Essential Tremor
Functional Neurological Disorder
Functional Cognitive Disorder
Alzheimer Disease
Interventions
A neurological examination following a protocol to detect positive signs of functional neurological disorders.
A standardized question about the patient´s history. The response time is measured. Question: "Could you tell me about the problems with the movement disorder you are experiencing?"
Neuropsychological cognitive testing including: * Montreal Cognitive Assessment (MOCA) * Rey-Osterrieth Complex Figure Test (ROCFT) * Wechsler Memory Scale IV * Comprehensive Trail Making Test (CTMT) * semantic and phonematic fluency tests
* Short Form 36 (SF 36) * Somatic Symptom Disorder - B Criteria Scale (SSD 12) * Patient Health Questionnaire 9 (PHQ 9) * Patient Health Questionnaire 15 (PHQ 15) * Generalized Anxiety Disorder 7 (GAD 7) * Fatigue Severity Scale (FSS) * Psychosomatic Competence Inventory (PSCI) * Work Ability Index (WAI) * Level of Personality Functioning Scale * Toronto Alexithymia Scale * Levels of Emotional Awareness Scale (short version) * Certainty About Mental States Questionnaire * Somatosensoric Amplification Scale * Personality Inventory for DSM-5 short version (PID5BF+M) * Childhood Trauma Questionnaire * European Quality of Life 5 Dimensions 5 Level Version (EQ5D5L)
Accelerometry following a standardized protocol, using a triaxial accelerometer transducer (Biometrics ACL300, Sensitivity 6 100 mV/G, Biometrics Ltd, UK)
Eligibility Criteria
Patients with functional and non-functional movement disorders of the Movement Disorders Outpatient Clinic of the Department of Neurology, Medical University of Graz
You may qualify if:
- Functional or non-functional movement disorder
- to 80 years
You may not qualify if:
- Patient is not able to consent
- Patient is not able to understand / speak German fluently (questionnaires are available only in German)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical University of graz
Graz, Styria, 8010, Austria
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 5, 2023
First Posted
July 13, 2023
Study Start
January 1, 2023
Primary Completion
December 31, 2025
Study Completion (Estimated)
June 30, 2026
Last Updated
September 29, 2025
Record last verified: 2025-09