Tick-borne Encephalitis Virus Research in Limousin

NCT05941546 | Completed

• 1 other identifier: 87RI23_0012
• Study Type: observational
• Target: 878
• Locations: 1 country
• Sites: 1

Brief Summary

Cases of encephalitis of varying severity have been described in recent years in eastern France involving tick-borne encephalitis virus (TBEV). The main objective is to demonstrate the presence of TBEV in Limousin, in patients with a positive Lyme serology, or a neurological picture compatible with TBEV.

Conditions

Tick-borne Encephalitis

Keywords

tick-borne encephalitis; TBEV; serology; PCR

Outcome Measures

Primary Outcomes (1)

• Detection of anti-TBEV antibodies in serum

  The primary endpoint is the detection of anti-TBEV antibodies in the serum of the study population.

  month 1

Secondary Outcomes (1)

• Search for the presence of TBEV in the CSF in case of positive serology. Determine the risk factors associated with this infection.

  month 2

Interventions

anti-TBEV serology DIAGNOSTIC_TEST

we will measure by ELISA in microplates the anti-TBEV IgG as well as the anti-TBEV IgM on the sera + in TBEV IgG. We will then send a patient questionnaire with an information note to document the context of this TBEV seropositivity and to eliminate false-positivities (vaccination). Finally, we will perform PCR on CSF if serum positive and CSF available

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with Lyme serology from our GLIMS laboratory software (with positive or negative results)

You may qualify if:

• Patient with Lyme serology. Neurological picture compatible with neuroborreliosis or encephalitis.
• No objection from the patient to the use of biobank samples

You may not qualify if:

• Patient's opposition.

Sponsors & Collaborators

• University Hospital, Limoges: lead

Study Sites (1)

Limoges University Hosiptal

Limoges, 87000, France

Location

Related Publications (1)

• Bisserier E, Perraud A, Ayhan N, Durand GA, de Lamballerie X, Hantz S. Serological evidence of tick-borne encephalitis virus in limousin, france. Int J Infect Dis. 2026 Apr;165:108424. doi: 10.1016/j.ijid.2026.108424. Epub 2026 Jan 27.

  PMID: 41610944 RESULT

MeSH Terms

Conditions

Encephalitis, Tick-Borne

Condition Hierarchy (Ancestors)

Encephalitis, Arbovirus; Encephalitis, Viral; Central Nervous System Viral Diseases; Central Nervous System Infections; Infections; Infectious Encephalitis; Arbovirus Infections; Vector Borne Diseases; Tick-Borne Diseases; Virus Diseases; RNA Virus Infections; Flavivirus Infections; Flaviviridae Infections; Encephalitis; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neuroinflammatory Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 4, 2023
• First Posted: July 12, 2023
• Study Start: July 17, 2023
• Primary Completion: August 13, 2023
• Study Completion: August 13, 2023
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)