OBEGEN
Results of Sequencing of a Large Panel of Genes From Leptin Melanocortin Pathway in Children Suffering From Severe Obesity
Sponsor study identifier
interventional
100
0 countries
N/A
Study Start
October 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 1, 2024
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Study Completion
January 1, 2025
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About 380 million children and adolescents suffer from overweight and obesity at the global level. Obesity results from the interplay between biological (sex, age, fetal programming, gut microbiota, epigenetics, and genetics) and environmental factors (e.g., unhealthy diet, physical inactivity, stress). Mutations in genes from leptin melanocortin pathway are involved in "non syndromic monogenic obesity", characterized by severe early onset obesity, hyperphagia and endocrine deficiencies. Exact frequencies of mutation in these genes are not precisely evaluated in french children with severe obesity. Moreover new treatment, such seltmelanotide are avalaible in case of certain mutation, leading to a significative weight loss in treated patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 1, 2025
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 12, 2023
Actual (reported)July 10, 2023
Actual (reported)October 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 1, 2024
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January 1, 2025
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frequency of mutations of genes from leptin melanocortin pathway
Evaluating of the frequency of mutations of 14 genes from leptin melanocortin pathway (LEP, LEPR, POMC, PCSK1, MC3R, MC4R, MRAP2, ADCY3, SIM1, SH2B1, NTRK2, BDNF, KSR2) in a group of french children with severe obesity.
1 year
Clinical characteristics of children with severe obesity followed in CHRU of Nancy
1 year
Clinical characteristics of children with mutations of leptin melanocortin pathway
1 year
Clinical characteristics of children with mutations of leptin melanocortin pathway
1 year
Clinical characteristics of children with mutations of leptin melanocortin pathway
1 year
Clinical characteristics of children with mutations of leptin melanocortin pathway
1 year
children with severe obesity with BMI \> 3sds
sequencing (NGS) of a panel of 14 genes in leptin melanocortin pathway in french children with severe obesity
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First Submitted
June 12, 2023
First Posted
July 10, 2023
Study Start
October 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 1, 2024
Management of Childhood Obesity
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
January 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 10, 2023
Record last verified: 2023-07
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Source: ClinicalTrials.gov.
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