A Comparative Study Between Honey and Alcohol as Topical Skin Disinfectant

NCT05937412 | Recruiting DMC

• 1 other identifier: MS 312/2022
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Skin antisepsis is essential in every healthcare environment. Alcohol/chlorhexidine use might disrupt skin microbiota and lead to antibiotic resistance. This study investigates honey (being natural product with many beneficial therapeutic effects) as topical skin anti-septic agent and compares it with alcohol, in terms of effectiveness and safety.

Conditions

Disinfectant Causing Toxic Effect

Outcome Measures

Primary Outcomes (1)

• Assess efficacy of honey as a disinfectant in comparison to the standard disinfectant which is alcohol

  taking a swab from skin for culture of organisms after application of either alcohol or honey and compare type of organisms and number of colony forming units

  3 months

Study Arms (2)

alcohol group

ACTIVE COMPARATOR

70% isopropyl alcohol will be topically applied and spread uniformly on a prespecified area of at least 3 cm x 3cm on the dorsum of the hand. A skin swab will be obtained from the selected skin area just before and 20 seconds after topical application of alcohol and honey.

Other: Alcohol sterilization

honey group

ACTIVE COMPARATOR

honey will be topically applied and spread uniformly on a prespecified area of at least 3 cm x 3cm on the dorsum of the hand. A skin swab will be obtained from the selected skin area just before and 20 seconds after topical application of alcohol and honey.

Other: Honey sterilization

Interventions

Alcohol sterilization OTHER

Sterilizing skin using alcohol

alcohol group

Honey sterilization OTHER

Sterilizing skin using honey

honey group

Eligibility Criteria

• Age: 2 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• \- Children aged from 2 to 12 years, of both sexes, and with apparently healthy skin.
• Children, who did not receive any form of antimicrobial agent for at least one-week prior study.

You may not qualify if:

• \- Immuno-compromised due to diseases or drugs.
• \- Children having any skin disease as eczema or others

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University, Cairo

Cairo, Cairo Governorate, 1181, Egypt

RECRUITING

Related Publications (11)

• Breasted JH. (1930): The Edwin Smith papyrus: published in facsimile and hieroglyphic transliteration. Chicago: University of Chicago Press.

  BACKGROUND

• Wiemken TL. Skin antiseptics in healthcare facilities: is a targeted approach necessary? BMC Public Health. 2019 Aug 22;19(1):1158. doi: 10.1186/s12889-019-7507-5.

  PMID: 31438910 BACKGROUND

• Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem. 2002 May 8;50(10):3050-5. doi: 10.1021/jf0114637.

  PMID: 11982440 BACKGROUND

• Hasyimi W, Widanarni W, Yuhana M. Growth Performance and Intestinal Microbiota Diversity in Pacific White Shrimp Litopenaeus vannamei Fed with a Probiotic Bacterium, Honey Prebiotic, and Synbiotic. Curr Microbiol. 2020 Oct;77(10):2982-2990. doi: 10.1007/s00284-020-02117-w. Epub 2020 Jul 18.

  PMID: 32683466 BACKGROUND

• Held E, Mygind K, Wolff C, Gyntelberg F, Agner T. Prevention of work related skin problems: an intervention study in wet work employees. Occup Environ Med. 2002 Aug;59(8):556-61. doi: 10.1136/oem.59.8.556.

  PMID: 12151613 BACKGROUND

• Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015 Mar 6;2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4.

  PMID: 25742878 BACKGROUND

• Majtan J. Honey: an immunomodulator in wound healing. Wound Repair Regen. 2014 Mar-Apr;22(2):187-92. doi: 10.1111/wrr.12117. Epub 2014 Feb 24.

  PMID: 24612472 BACKGROUND

• Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011 Apr;1(2):154-60. doi: 10.1016/S2221-1691(11)60016-6.

  PMID: 23569748 BACKGROUND

• Christensen GJ, Bruggemann H. Bacterial skin commensals and their role as host guardians. Benef Microbes. 2014 Jun 1;5(2):201-15. doi: 10.3920/BM2012.0062.

  PMID: 24322878 BACKGROUND

• Sato T, Miyata G. The nutraceutical benefit, part iii: honey. Nutrition. 2000 Jun;16(6):468-9. doi: 10.1016/s0899-9007(00)00271-9. No abstract available.

  PMID: 10869910 BACKGROUND

• Trevisanato SI. Treatments for burns in the London Medical Papyrus show the first seven biblical plagues of Egypt are coherent with Santorini's volcanic fallout. Med Hypotheses. 2006;66(1):193-6. doi: 10.1016/j.mehy.2005.08.052. Epub 2005 Oct 14.

  PMID: 16226847 BACKGROUND

MeSH Terms

Interventions

Ethanol

Intervention Hierarchy (Ancestors)

Alcohols; Organic Chemicals

Study Officials

• mamdouh abdelmaksoud

  Ain Shams University

  STUDY DIRECTOR

• yosra awad

  Ain Shams University

  STUDY DIRECTOR

• maha ahmad

  Ain Shams University

  STUDY DIRECTOR

Central Study Contacts

ahmed badr

CONTACT

00201093562378; abn777777@yahoo.com

yosra awad

CONTACT

00201001831590; yosraawad@med.asu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 10, 2022
• First Posted: July 10, 2023
• Study Start: August 30, 2023
• Primary Completion: July 15, 2025
• Study Completion: August 28, 2025
• Last Updated: May 7, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)