The Impact of Aortic Valve Compression During Cardio-pulmonary Resuscitation on Patients With Out-of-hospital Cardiac Arrest

NCT05932784 | Completed

• 1 other identifier: 109070-F-2
• Study Type: observational
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose: This study aims to find out if the current way of performing chest compressions during resuscitation for patients who have suffered a cardiac arrest outside of the hospital is affecting their chances of recovery. Recent research suggests that more than half of these patients receive chest compressions near their aortic valve, which might block blood flow and make their condition worse. We will use a special imaging technique called transesophageal echocardiography (TEE) during resuscitation to see if compressions near the aortic valve impact patient outcomes. Methods: We will conduct a study with patients who have suffered a cardiac arrest outside of the hospital and are receiving TEE during resuscitation in the emergency department. Some patients will not be included in the study, such as those who recover quickly before the TEE is done, those who need other treatments before they recover, those with an unclear compression site, or those with poor or missing TEE images. We will divide the patients into two groups: those with compressions near their aortic valve and those without. We will collect information on the patients, the TEE recordings, the resuscitation process, and important time points. We will mainly look at whether the patients recover and maintain a steady heartbeat. We will also examine other factors like their carbon dioxide levels, whether they recover at all, if they survive to be admitted to the hospital, if they survive to be discharged, and if they have good brain function when they leave the hospital. We plan to have 37 patients in each group for accurate results.

Conditions

Out-Of-Hospital Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• sustained return of spontaneous circulation (ROSC)

  successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes

  20 minutes after ROSC

Secondary Outcomes (5)

• Any return of spontaneous circulation (ROSC)

  1 minutes after ROSC

• survival to admission

  48 hours after ROSC

• survival to discharge

  6 months after ROSC

• discharge with favorable neurological outcomes

  6 months after ROSC

• end-tidal carbon dioxide (EtCO2)

  During resuscitation

Study Arms (1)

OHCA patients receiving TEE

Out-of-hospital cardiac arrest (OHCA) patients undergo transesophageal echocardiography (TEE) during resuscitation to determine if their aortic valve is being compressed.

Device: transesophageal echocardiography

Interventions

transesophageal echocardiography DEVICE

Utilizing transesophageal echocardiography (TEE) during resuscitation allows medical professionals to determine if a patient's aortic valve is being compressed while receiving chest compressions, providing valuable insight to optimize the resuscitation process.

Also known as: TEE

OHCA patients receiving TEE

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 20 or older who arrived at the ED with non-traumatic OHCA and underwent TEE during resuscitation were enrolled, except for those meeting the following exclusion criteria: 1) Early ROSC before obtaining TEE image; 2) Insertion of REBOA before ROSC; 3) Initiation of ECMO flow before ROSC; 4) Unidentifiable compression site on TEE; 5) Poor quality TEE image; 6) Missing TEE image

You may qualify if:

• patients aged 20 or older who arrived at the ED with non-traumatic OHCA and underwent TEE during resuscitation

You may not qualify if:

• Early ROSC before obtaining TEE image;
• Insert the REBOA before ROSC;
• Initiate ECMO flow before ROSC;
• Cannot identify compression site on TEE;
• Poor quality of TEE image;
• Missing TEE image.

Sponsors & Collaborators

• Far Eastern Memorial Hospital: lead

Study Sites (1)

Far Eastern Memorial Hospital

Banqiao District, New Taipei City, 220, Taiwan

Location

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Interventions

Echocardiography, Transesophageal

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Echocardiography; Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 27, 2023
• First Posted: July 6, 2023
• Study Start: October 1, 2020
• Primary Completion: January 31, 2023
• Study Completion: May 1, 2023
• Last Updated: July 6, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)