Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD

NCT05927506 | Completed

• 1 other identifier: IRB00064633
• Study Type: observational
• Target: 312
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to examine the developmental trajectory of response control in boys and girls with ADHD entering adolescence. The investigators also want to determine the developmental trajectory of brain anatomy and brain connectivity in boys and girls with ADHD entering adolescence.

Conditions

ADHD; Attention Deficit Hyperactivity Disorder

Keywords

Cognitive Testing; Typically Developing; Motor Control; Gender Differences

Outcome Measures

Primary Outcomes (4)

• Response Control and Frustration Tolerance

  Go/No-Go (GNG) reaction time task related to working memory and motivation. Each task will take place in a single block of 207 trials (80% green), with no rest phases (total duration = 8min, 19 sec). For the motivational GNG task, stimulus presentation will be followed by a blank screen (1000ms), the presentation of visual feedback (1700ms), and another blank screen (500ms). Reward feedback will be presented for correct "go" responses and response cost feedback will be presented for commission errors.

  Completed on Day 1 or Day 2 Visit

• Developmental Trajectory of Brain Anatomy

  The Primary outcome variables will be morphometry of cortical regions (thickness, surface area, folding index, volume) and subcortical regions (basal ganglia, amygdala, and hippocampus volume and shape).

  Completed on Day 1 or Day 2 Visit

• Predictors of Adolescent Socio-Emotional Development

  Behavior Assessment System for Children (BASC-3) is a questionnaire used to assess behavioral and emotional functioning in children. The parent-report, teacher-report, and self-report versions will be administered to collect behavioral and emotional values.

  Completed on Day 1 or Day 2 Visit

• Developments of ADHD Symptoms

  Conners-4 is a questionnaire to values on conduct and learning problems, impulsivity-hyperactivity, anxiety, and social competence. Parent-report and teacher-report will be administered collect values to determine ADHD symptom severity.

  Completed on Day 1 or Day 2 Visit

Study Arms (2)

Adolescents with ADHD

Observational study of behavior cognitive and motor control

Behavioral: Other

Adolescents without ADHD

Observational study of behavior cognitive and motor control

Behavioral: Other

Interventions

Other BEHAVIORAL

Observational study of behavior cognitive and motor control

Adolescents with ADHD; Adolescents without ADHD

Eligibility Criteria

• Age: 12 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Male and Female adolescents within the age range of 12-17 years old, with or without a diagnosis of Attention Deficit Hyperactivity Disorder

You may qualify if:

• Diagnosed with or without Attention Deficit Hyperactivity Disorder
• Must be able to attend a follow-up after 18 months after initial visit

You may not qualify if:

• Diagnosed with Autism Spectrum Disorder (ASD)
• Diagnosed with Schizophrenia, Conduct Disorder, and/or Bipolar Disorder
• Diagnosed with a genetic disorder
• Premature birth (less than 36 weeks)

Sponsors & Collaborators

• Hugo W. Moser Research Institute at Kennedy Krieger, Inc.: lead
• Johns Hopkins University: collaborator

Study Sites (1)

Kennedy Krieger Insititute

Baltimore, Maryland, 21205, United States

Location

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Stewart Mostofsky, Ph.D

  Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2023
• First Posted: July 3, 2023
• Study Start: July 1, 2015
• Primary Completion: June 30, 2023
• Study Completion: June 30, 2023
• Last Updated: August 20, 2025

Record last verified: 2025-08

Locations

US (1)