Early Body Temperature Targets and Relationship With Prognosis in Patients With Heat Stroke
1 other identifier
observational
100
1 country
6
Brief Summary
The goal of this observational study is to explore the optimal target body temperature in first 24 hours and the relationship between body temperature and adverse outcomes of heat stroke. The main questions it aims to answer are:
- the optimal target body temperature at 0.5 h, 2 h, and the lowest body temperature of heat stroke.
- the best body temperature at the cutting point of stop cooling.
- The relationship between the volume and speed of ice saline infusion and the cooling effect.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2023
Typical duration for all trials
6 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 23, 2023
CompletedStudy Start
First participant enrolled
May 28, 2023
CompletedFirst Posted
Study publicly available on registry
June 27, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2026
CompletedSeptember 20, 2024
September 1, 2024
2.3 years
May 23, 2023
September 18, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
mortality
Number of participants who dead during hospitalization
up to 90 days
organ damage
Number of participants with organ damage, including but not limited to brain, lung, heart, kidney, liver and coagulation
up to 90 days
Secondary Outcomes (3)
continuous renal replacement therapy
up to 90 days
length of ICU stay
up to 90 days
length of hospital stay
up to 90 days
Study Arms (1)
Patients with heat stroke
Patients with heat stroke presenting to the emergency department at the study site
Interventions
This study is an observational study. Patients will receive conventional cooling measures and organ function support.
Eligibility Criteria
Comprehensive tertiary hospital
You may qualify if:
- ≥ 18 years; ② diagnosed as heat stroke; ③ Informed consent from patients or family members.
You may not qualify if:
- need immediate cardiopulmonary resuscitation; ② transferred from another hospital; ③ with severe underlying organ insufficiency; ④ pregnant women.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Second Affiliated Hospital, School of Medicine, Zhejiang Universitylead
- Yiwu Central Hospitalcollaborator
- Jinhua People's Hospitalcollaborator
- Jinhua Municipal Central Hospitalcollaborator
- Dongyang People's Hospitalcollaborator
- Lanxi People's Hospitalcollaborator
Study Sites (6)
Yiwu Central Hospital
Yiwu, Zhejiang, China
Dongyang People's Hospital
Dongyang, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, 310000, China
Jinhua Municipal Central Hospital
Jinhua, China
Jinhua People's Hospital
Jinhua, China
Lanxi People's Hospital
Lanxi, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lan Chen
Second Affiliated Hospital, School of Medicine, Zhejiang University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 23, 2023
First Posted
June 27, 2023
Study Start
May 28, 2023
Primary Completion
October 1, 2025
Study Completion
March 1, 2026
Last Updated
September 20, 2024
Record last verified: 2024-09