White-coat Hypertension in Childhood - Effects on Blood Pressure and Organ Damage

NCT05919420 | Completed

• 1 other identifier: WCH
• Study Type: observational
• Target: 56
• Locations: 0 countries
• Sites: N/A

Brief Summary

White coat hypertension, WCH means that the blood pressure are above normal values only when measured at visits to the doctor, but not at home. WCH has in adults proved to be predisposing to the development of hypertension, and damage to the heart and arteries. It is not known if children and young people run the same risk as adults with WCH. The investigators have previously examined the blood pressure of 1473 healthy children and adolescents in the study "Screening for high blood pressure and silent kidney disease in school children" and the results were published recently in the American Journal of Hypertension. In the study, we identified a number of participants who had the WCH. The investigators are implementing now, 10 years later, a follow-up study to investigate if these children with WCH have an increased risk of hypertension and subsequent cardiovascular disease. The goal is to investigate whether these young individuals are at similar risk as adults with WCH for hypertension and impaired cardiovascular function. The investigators will provide our WCH participants extended examinations of the heart, blood vessels and kidney function, which will provide important information as to whether there are effects on cardiovascular health already in adolescence among participants that suffered from WCH in childhood. This is important knowledge in clinical work in order to learn how to best care for these children to minimize their risk of future disease.

Conditions

White Coat Hypertension

Outcome Measures

Primary Outcomes (3)

• Hypertension

  blood pressure at hypertensive level

  at follow up (average 9,3 years after baseline)

• Left ventricular hypertrophy

  echocardiographic measurment

  at follow up (average 9,3 years after baseline)

• vascular elasticity

  pulse wave velocity

  at follow up (average 9,3 years after baseline)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

56 participants with WCH that were identified in a previous study

You may qualify if:

• being identified in our previous study as having WCH

You may not qualify if:

• none

Sponsors & Collaborators

• Karolinska Institutet: lead

MeSH Terms

Conditions

White Coat Hypertension

Condition Hierarchy (Ancestors)

Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical doctor, PhD

Study Record Dates

• First Submitted: December 9, 2015
• First Posted: June 26, 2023
• Study Start: September 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2017
• Last Updated: September 19, 2024

Record last verified: 2023-06