Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
1 other identifier
observational
100
1 country
1
Brief Summary
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS). These 3 inflammatory cardiac diseases have clinical, biological, and echographic similarities and differences. Nevertheless their modalities of monitoring, management and evolution are different. The investigators wish to retrospectively analyze biological and echocardiographic data of Kawasaki disease, myocarditis, PIMS patients managed at Nancy Children Hospital from January 1, 2017 to June 31, 2023. The primary objective of this study is to identify, for these 3 pathologies, the prognostic factors of initiation of inotropic support. The secondary objective is to identify the prognostic factors of degradation of ventricular function.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2023
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 9, 2023
CompletedFirst Posted
Study publicly available on registry
June 22, 2023
CompletedStudy Start
First participant enrolled
September 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2023
CompletedAugust 30, 2023
August 1, 2023
Same day
May 9, 2023
August 29, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
need of hemodynamic support
The need for haemodynamic support is defined dichotomously: yes or no. The investigators wish to identify the predictive factors of need for haemodynamic support among the following variables: groups (PIMS, KAWASAKI, MYOCARDITIS), cardiac biomarkers (troponin and NT-pro-BNP at admission (in ng/ml)) and echocardiographic criterias (Left Ventricular Ejection fraction, global and regional longitudinal strain at admission (in %)).
up to 20 days
Secondary Outcomes (1)
deterioration of Left Ventricular Ejection fraction
up to 20 days
Study Arms (3)
MYOCARDITIS
No intervention Study of available clinical, biological, and echocardiographic data
KAWASAKI
No intervention Study of available clinical, biological, and echocardiographic data
PIMS
No intervention Study of available clinical, biological, and echocardiographic data
Interventions
observational study : there is no intervention
Eligibility Criteria
age \< 18 years initial management and follow up in Nancy university children hospital center for PIMS Myocarditis and Kawasaki disease patients
You may qualify if:
- diagnostic of PIMS, myocarditis or kawasaki disease patients
- age \< 18 years
You may not qualify if:
- uncertain diagnosis
- other complex heart disease
- management out of Nancy University children hospital center
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Gilles BOSSER
Vandœuvre-lès-Nancy, 54511, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- chief of congenital and pediatric cardiology department
Study Record Dates
First Submitted
May 9, 2023
First Posted
June 22, 2023
Study Start
September 1, 2023
Primary Completion
September 1, 2023
Study Completion
September 1, 2023
Last Updated
August 30, 2023
Record last verified: 2023-08
Data Sharing
- IPD Sharing
- Will not share