Gathering Evidence on Best Practices for Lay Rescuer CPR Training

NCT05908500 | Not Yet Recruiting DMC

• 1 other identifier: Lay Rescuer CPR Training 2026
• Study Type: interventional
• Target: 2,100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this prospective trial is to compare CPR skill and attitudes in lay rescuers. The main question\[s\] it aims to answer are:

• What is the optimal training timing, duration, and frequency for lay rescuers that leads to CPR skill retention?
• What is the impact of CPR manikin type (high-fidelity, inflatable, nontraditional objects) on skill retention?
• How do specific features of training modality -- such as contextualization, gamification, and emotional engagement -- impact skill proficiency, knowledge retention, and attitudes about CPR? Participants will
• Answer pre-training questionnaires
• Participate in CPR training
• Participate in CPR skills testing
• Answer post-training questionnaires Researchers will compare different methods of training, different frequencies of training, and different manikin types.

Conditions

Cardiac Arrest, Out-Of-Hospital

Keywords

Cardiopulmonary Resuscitation; cardiopulmonary resuscitation training; Lay Rescuer cardiopulmonary resuscitation; lay rescuer cardiopulmonary resuscitation training

Outcome Measures

Primary Outcomes (1)

• CPR Skill Retention

  High-quality CPR as measured by compression rate (per minute), depth (inches), and correct hand placement. High-quality CPR is defined as correct rate (100-120/min) AND \>70% of compressions at appropriate depth (2-2.4inches) with appropriate hand placement.

  1-4 years

Secondary Outcomes (4)

• CPR Attitudes

  1-4 years

• CPR Knowledge Retention

  1-4 years

• Emotional Profile

  1-4 years

• Learner Engagement

  1-4 years

Other Outcomes (1)

• Training Feature Effects (Contextualization, Gamification, Emotional Impact)

  1-4 years

Study Arms (9)

Every 2 year standard CPR training

ACTIVE COMPARATOR

Receives two 60-minute instructor-led CPR trainings: once in 9th grade and again in 11th grade

Behavioral: CPR Training

Annual Standard CPR training

ACTIVE COMPARATOR

Receives a 60-minute instructor-led CPR training each year for three years.

Behavioral: CPR Training

High-Frequency, Blended Training

ACTIVE COMPARATOR

Starts with a 30-minute serious game-based session, followed by 10-minute refreshers every semester for four years (8 total sessions).

Behavioral: CPR Training

Annual Serious Game Training

ACTIVE COMPARATOR

Receives a 30-minute serious game-based training session once per year for three years.

Behavioral: CPR Training

Control

NO INTERVENTION

No CPR training

Standard High-fidelity Manikin

ACTIVE COMPARATOR

Uses a commercially available torso manikin with realistic chest mechanics and feedback. Serves as the gold standard comparator for CPR training.

Device: CPR Manikin Type

Low-Fidelity Manikin

ACTIVE COMPARATOR

Uses a basic inflatable torso manikin with minimal feedback or resistance. Represents a low-cost, commonly used alternative in schools and communities.

Device: CPR Manikin Type

No-Head Manikin (Prototype)

ACTIVE COMPARATOR

Uses a custom-built spring-based device with a silicone topper and realistic force-displacement properties that closely mimic the human chest. Tests whether an affordable, biomechanically accurate prototype can improve compression quality.

Device: CPR Manikin Type

Non-Traditional Object

ACTIVE COMPARATOR

Uses improvised materials (e.g., toilet paper rolls) to simulate chest compressions. Evaluates the feasibility and effectiveness of ultra-low-cost CPR practice tools

Device: CPR Manikin Type

Interventions

CPR Training BEHAVIORAL

Various durations and frequencies of CPR training

Annual Serious Game Training; Annual Standard CPR training; Every 2 year standard CPR training; High-Frequency, Blended Training

CPR Manikin Type DEVICE

Various types of CPR manikins are compared

Low-Fidelity Manikin; No-Head Manikin (Prototype); Non-Traditional Object; Standard High-fidelity Manikin

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All students at participating schools

You may not qualify if:

• Previous CPR training (will be included in the CPR training but excluded from analysis)
• Physical injury which prevents performing CPR
• Student or parent opt-out

Sponsors & Collaborators

• University of Nevada, Reno: lead

Study Sites (1)

University of Nevada Reno

Reno, Nevada, 89557, United States

Location

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases

Study Officials

• Lorrel Toft

  University of Nevada, Reno

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lorrel Toft, MD

CONTACT

4103028456; ltoft@unr.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The statistical analysis will be masked as to which intervention subjects received, with simple "A," "B," etc. designation.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Medicine

Model Details: Aim 1: A 4-year, cluster-randomized trial at a rural high school evaluates the impact of CPR training frequency and duration on skill retention, confidence, and emotional readiness. Students (N\~1,200) are assigned by class year to different training schedules using standard, gamified, or brief refresher formats. CPR skills, knowledge, and psychosocial outcomes are assessed annually. Aim 2: A 2-year, individually randomized trial at a suburban high school compares four chest compression practice tools: high-fidelity manikin, low-fidelity manikin, a novel "no-head" manikin, and improvised objects. Ninth-grade students (N\~432) are assessed post-training and at 1 year for CPR skill quality (rate, depth, recoil, hand placement) using objective measurement tools.

Study Record Dates

• First Submitted: January 13, 2023
• First Posted: June 18, 2023
• Study Start: April 1, 2026
• Primary Completion (Estimated): March 31, 2030
• Study Completion (Estimated): March 31, 2031
• Last Updated: June 4, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)