The Quality of Life in Individuals With Parkinson's Disease

NCT05906693 | Completed

• 2 other identifiers: 60116787-020/459912019SABE021
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease. The differences between Parkinson's Disease Quality of Life Questionnaire, Nine-Hole Peg Test, grip and pinch strength values in the individuals with and without tremor in the study were investigated.

Conditions

Parkinson Disease; Tremor; Functionality

Keywords

Quality of Life; Upper Limb Functionality; Tremor; Electromyography; Parkinson's Disease

Outcome Measures

Primary Outcomes (6)

• Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale

  The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale. Used for the evaluation of clinical manifestations of Parkinson's disease. The scale consists of 4 subscales: the first part is Non-Motor Aspects of Experiences of Daily Living (13), the second part is Motor Aspects of Experiences of Daily Living (13), the third part is Motor Examination (33), and the fourth part is Motor Complications (6). The total number of items in the scale is 65. The minimum score is 0. The maximum MDS-UPDRS score is higher, given the additional items and scores for each body area, with a maximum score of 272. Higher scores indicate greater impact of Parkinson Disease symptoms.

  1 year

• Hospital Anxiety and Depression Scale

  The Hospital Anxiety and Depression Scale aims to measure symptoms of anxiety and depression and consists of 14 items, seven items for the anxiety subscale (Hospital Anxiety and Depression Scale Anxiety) and seven for the depression subscale (Hospital Anxiety and Depression Scale Depression). Each item is scored on a response-scale with four alternatives ranging between 0 and 3. After adjusting for six items that are reversed scored, all responses are summed to obtain the two subscales. Both depression and anxiety subheadings are scored between 0 and 21. Higher scores indicate greater levels of anxiety or depression. Cut-off scores are 8-10 for doubtful cases and ≥11 for definite cases.

  1 year

• Parkinson's Disease Quality of Life Questionnaire (PDQ-39)

  Used to assess the quality of life of Parkinson's patients

  1 year

• Electromyography

  Used to assess the tremor amplitude of Parkinson's patients

  1 year

• Nine-Hole Peg Test

  Used to assess the upper limb functionality of Parkinson's patients

  1 year

• Dynamometer

  Used to assess the grip and pinch strength of Parkinson's patients

  1 year

Interventions

Quality of life OTHER

Parkinson's Disease Quality of Life Questionnaire (PDQ-39)

Upper limb functionality OTHER

Nine-Hole Peg Test

Grip and pinch strength OTHER

Dynamometer

Tremor amplitude OTHER

Electromyography

Depression and anxiety levels OTHER

Hospital Anxiety and Depression Scale

Clinical manifestations OTHER

The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals with Parkinson Disease were included in the study

You may qualify if:

• Definite diagnosis of idiopathic Parkinson Disease
• Age between 40 and 80 years
• Being literate
• Having a grade between 1-4 from the Modified Hoehn and Yahr Scale
• Having a score lower than 11 in Hospital Anxiety and Depression Scale

You may not qualify if:

• Who were with any other neurologic or orthopedic or rheumatologic disease affecting the upper extremity
• Using antidepressants
• Having vision loss
• Deep brain stimulation

Sponsors & Collaborators

• Pamukkale University: lead

Study Sites (1)

Pamukkale University

Denizli, Pamukkale, 20190, Turkey (Türkiye)

Location

Related Publications (3)

• Kuhlman GD, Flanigan JL, Sperling SA, Barrett MJ. Predictors of health-related quality of life in Parkinson's disease. Parkinsonism Relat Disord. 2019 Aug;65:86-90. doi: 10.1016/j.parkreldis.2019.05.009. Epub 2019 May 7.

  PMID: 31118162 BACKGROUND

• Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G; Tremor Task Force of the International Parkinson and Movement Disorder Society. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018 Jan;33(1):75-87. doi: 10.1002/mds.27121. Epub 2017 Nov 30.

  PMID: 29193359 BACKGROUND

• Louis ED, Machado DG. Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients. Parkinsonism Relat Disord. 2015 Jul;21(7):729-35. doi: 10.1016/j.parkreldis.2015.04.019. Epub 2015 Apr 24.

  PMID: 25952960 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease; Tremor

Interventions

Quality of Life; Hand Strength; Pinch Strength

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Health Status; Demography; Epidemiologic Measurements; Public Health; Environment and Public Health; Muscle Strength; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Buse KILINÇ, PT.MSc.

  Pamukkale University

  PRINCIPAL INVESTIGATOR

• Nilüfer ÇETİŞLİ-KORKMAZ, PT.PhD.Prof.

  Pamukkale University

  STUDY DIRECTOR

• Levent S. BIR, MD.PhD.Prof.

  Pamukkale University

  STUDY CHAIR

• Ahmet D. MARANGOZ, MD.

  Klinikum Stuttgart

  STUDY CHAIR

• Hande ŞENOL, Assist.Prof.

  Pamukkale University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PT.MSc.

Study Record Dates

• First Submitted: June 7, 2023
• First Posted: June 18, 2023
• Study Start: January 1, 2019
• Primary Completion: November 20, 2020
• Study Completion: July 13, 2021
• Last Updated: June 18, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)