NCT05898230

Brief Summary

The objective of this study is to evaluate the medium- to long-term safety of the Carbomedics OptiForm Mitral Heart Valve after the implantation for mitral valve disease in the Chinese population. The study is designed as a post-market, retrospective, single arm and multicentric data collection

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
400

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2023

Shorter than P25 for all trials

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 1, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

June 12, 2023

Completed
5 months until next milestone

Study Start

First participant enrolled

November 23, 2023

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2024

Completed
Last Updated

March 7, 2024

Status Verified

March 1, 2024

Enrollment Period

1 year

First QC Date

June 1, 2023

Last Update Submit

March 6, 2024

Conditions

Outcome Measures

Primary Outcomes (7)

  • Prosthetic Valve Dysfunction

    The number and percentage of subjects with Prosthetic valve Dysfuntion

    up to 7-8 year

  • Mortality

    The number and percentage of subjects died

    up to 7-8 year

  • Valve-related bleeding

    The number and percentage of subjects with Valve-related bleeding

    up to 7-8 year

  • Valve thrombosis

    The number and percentage of subjects with Valve Thrombosis

    up to 7-8 year

  • Thromboembolism

    The number and percentage of subjects with Thromboembolic events

    up to 7-8 year

  • Endocarditis

    The number and percentage of subjects with Endocarditis

    up to 7-8 year

  • Valve-Related Reintervention

    The number and percentage of subjects underwent Valve-related reintervention

    up to 7-8 year

Study Arms (1)

Subjects who have been implanted with the Carbomedics OptiForm Mitral Heart Valve

Mitral Valve Replacement with Carbomedics OptiForm Mitral Heart Valve

Device: Mitral Valve Replacement

Interventions

Mitral Valve Replacement with Carbomedics OptiForm Mitral Heart Valve

Subjects who have been implanted with the Carbomedics OptiForm Mitral Heart Valve

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Subjects who have been implanted with the Carbomedics OptiForm Mitral Heart Valve

You may qualify if:

  • Subject who has been treated with the Carbomedics OptiForm Mitral Heart Valve.
  • Subject (or representative or family member) who can understand the objective of the study and is willing to provide verbal informed consent and the available medical information.

You may not qualify if:

  • Subject (or legal representative or family member) who do not provide their verbal consent to the data collection, or who are unable to provide follow-up information

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

The second Xiangya Hospital of Central South University

Changsha, China

RECRUITING

West China hospital of Sichuan University

Chendu, China

RECRUITING

Study Officials

  • Sara Gaggianesi

    Corcym S.r.l

    STUDY DIRECTOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 1, 2023

First Posted

June 12, 2023

Study Start

November 23, 2023

Primary Completion

December 1, 2024

Study Completion

December 1, 2024

Last Updated

March 7, 2024

Record last verified: 2024-03

Locations