Investigating the Pathophysiological Nature of Homosexuality

NCT05897177 | Recruiting

• 1 other identifier: 3255
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Debate continues on whether or not male homosexuality (MH) is a result of biological or cultural factors. The debate persists despite the fact that these two sides have different abilities to create a scientific environment to support their cause. Biological theorists produced evidence, however, that these are not always robust. On the other hand, social theorists, without direct evidence confirming their positions, criticize, with good argument, methods and results of the other side.

Conditions

Psychiatric Disorder

Outcome Measures

Primary Outcomes (3)

• Change of Symptom Checklist-90-Revised (SCL-90-R) from baseline to 34 weeks

  The SCL-90-R Is an inventory developed to assess the intensity of symptoms inventoried during the last weeks. Each of the 90 items that is integrated in the self-report questionnaire is answered in a likert scale from 0 (nothing) to 4 (a lot), depending on the intensity with which the subject has lived in the last weeks the discomfort that each one explores. It is evaluated and interpreted in function of 10 primary dimensions (somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychotic and diverse symptoms and three global indexes of psychological disorders.

  from baseline to 34 weeks

• Change of Sexual Compulsivity Scale (SCS) from baseline to 34 weeks

  The SCS contains 10 items (e.g., "my desires to have sex have disrupted my daily life"), rated from 1 (not at all like me) to 4 (very much like me). Item responses are summed to derive an overall score (range 10-40). A score of 24 or higher is frequently used to distinguish problematic sexual compulsivity

  from baseline to 34 weeks

• Change of Safer Sex Self-Efficacy Questionnaire (SSSE) from baseline to 34 weeks

  The 13-item SSSE assesses self-efficacy for condom use in various situations (e.g., "When you really need affection," "When your partner says he/she does not want to use a condom") in response to the prompt, "How confident are you that you could avoid having anal sex without a condom?" using a scale ranging from 1 (not at all tempted) to 5 (extremely tempted). The SSSE predicts condomless anal intercourse among men who have sex with men (MSM; Rendina, 2014).

  from baseline to 34 weeks

Secondary Outcomes (3)

• Change of Measure of Gay-Related Stress (MOGS) from baseline to 34 weeks

  from baseline to 34 weeks

• Change of Internalized Homophobia Scale (IHP) from baseline to 34 weeks

  from baseline to 34 weeks

• Change of Sexual Orientation Concealment Scale (SOCS) from baseline to 34 weeks

  from baseline to 34 weeks

Study Arms (2)

Normal patients

Behavioral: Subjective Scale of Stigma and Discrimination (SISD).

Observational group

Behavioral: Subjective Scale of Stigma and Discrimination (SISD).

Interventions

Subjective Scale of Stigma and Discrimination (SISD). BEHAVIORAL

Subjective Scale of Stigma and Discrimination (SISD) A sixdimension self-administered scale will be used that included statements with which the participants agreed or disagreed. The scale consists of 23 Likert-type items and responses range from 1 ("completely in disagreement") to 5 ("completely in agreement"), grouped together to represent the six indicators making up this part of the scale

Normal patients; Observational group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: male
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All individuals with homosexuality from these different locations, Egypt, England, China, and Mexico.

You may qualify if:

• Age ≥ 18 years
• Male will be included

You may not qualify if:

• Patients taking testosterone or its derivative.
• Patients taking anabolic steroids.
• Multi-sexual behaviours.
• HIV patients.
• not having and addictive disorder

Sponsors & Collaborators

• Mostafa Bahaa: lead
• Mostafa Mahmoud Bahaa Clinical Pharmacy Department, Horus University, New Damietta, Egypt: collaborator

Study Sites (1)

Tanta Unuversity

Tanta, 31527, Egypt

RECRUITING

MeSH Terms

Conditions

Mental Disorders

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Teaching assisstant

Study Record Dates

• First Submitted: May 28, 2023
• First Posted: June 9, 2023
• Study Start: July 20, 2023
• Primary Completion (Estimated): November 20, 2027
• Study Completion (Estimated): April 20, 2028
• Last Updated: March 16, 2026

Record last verified: 2026-03

Locations

EG (1)