Effects of Oxytocin on the Functional Architecture of the Brain Before and After Prolonged Naturalistic Fear Induction

NCT05896553 | Completed

• 1 other identifier: UESTC-BAM-08
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

The main aim of the pharmacological resting-state fMRI study is to investigate the modulatory effects of intranasal Oxytocin (24IU) on task and intrinsic functional connectivity before and after prolonged exposure to naturalistic fear induction via a movie.

Conditions

Healthy

Keywords

Oxytoxin; Fear; fMRI; Functional Connectivity

Outcome Measures

Primary Outcomes (1)

• Functional connectivity during the resting state between brain systems involved in emotional processing.

  1.During the 8min resting state before and after the movie clips the intrinsic connectivity of the brain will be assessed. The intrinsic connectivity will be computed as temporal correlation between spatially remote neurophysiological events, expressed as deviation from statistical independence across these events in distributed neuronal groups and areas. Effects of Oxytocin on the intrinsic architecture of the brain will be examined by comparing the Oxytocin- and Placebo- treated groups.

  Change between the time windows 72-80 minutes (before emotion induction) and 90-98 minutes (after emotion induction) following treatment

Secondary Outcomes (1)

• Functional and dynamic connectivity during the movie clip will be examined during the fear-induction period (10min movie clip).

  80 minutes to 90 minutes after treatment

Study Arms (2)

Oxytoxin group

EXPERIMENTAL

Drug: intranasal Oxytocin(24IU)

Drug: intranasal Oxytocin(24IU)

Placebo group

PLACEBO COMPARATOR

Drug: intranasal Placebo

Drug: intranasal Placebo

Interventions

intranasal Oxytocin(24IU) DRUG

Administration of intranasal Oxytocin(24IU)

Oxytoxin group

intranasal Placebo DRUG

Administration of intranasal Placebo

Placebo group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects without past or current psychiatric or neurological disorders
• Right-handedness
• Normal or corrected-normal version

You may not qualify if:

• History of head injury
• Medical or psychiatric illness
• Hypertension
• General cardio-vascular alteration or diseases
• Allergy against medications
• Visual or motor impairments
• Claustrophobia
• Drug addiction
• Nicotine dependence
• FMRI contradictions

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

University of Electronic Science and Technology of China

Chengdu, Sichuan, 611731, China

Location

Study Officials

• Benjamin Becker, Dr.

  University of Electronic Science and Technology of China

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Randomized placebo-controlled double-blind between-subject design

Study Record Dates

• First Submitted: May 29, 2023
• First Posted: June 9, 2023
• Study Start: May 29, 2023
• Primary Completion: April 1, 2024
• Study Completion: April 15, 2024
• Last Updated: April 4, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)