The Value of Doppler Study of Central Retinal Artery in Diagnosis of Increased ICP

NCT05891678 | Completed

• 1 other identifier: CRA doppler in increased ICP
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the diagnostic value of central retinal artery Doppler study in case of increased intracranial pressure.

Conditions

Increased Intracranial Pressure

Outcome Measures

Primary Outcomes (3)

• Central retinal artery resistivity index

  Central retinal artery resistivity index computed by PSV (cm/s ) and EDV (cm/s) reflects vascular resistance peripheral to the measuring location. The present study evaluate the correlation of Central retinal artery resistive index with increased intracranial pressure .

  From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 6 months

• peak systolic velocity ( cm/s)

  on a doppler waveform PSV correspond to each tall "peak " in the spectrum window calculated by build in software

  From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 6 months

• end diastolic velocity ( cm/s )

  on a doppler waveform EDV correspond to the point marked at the end of the cardiac cycle calculated by build in software

  From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 6 months

Study Arms (2)

Control group (N)

NO INTERVENTION

Central retinal artery Doppler in patient with normal ICP

Intervention group (H)

ACTIVE COMPARATOR

Central retinal artery Doppler in patient with increased ICP

Radiation: doppler study of central retinal artery

Interventions

doppler study of central retinal artery RADIATION

pulsed wave Doppler after decreasing the sample volume to fit inside the center of CRA. We will measure the peak systolic velocity (PSV), end diastolic velocity (EDV), and the resistivity index which equal PSV-EDV/PSV, we will measure 3 times and the expected normal value is less than 0.7.

Intervention group (H)

Eligibility Criteria

• Age: 14 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All Patients with cerebral stroke either ischemic or hemorrhagic
• All Patients with traumatic brain injury including those on mechanical ventilation

You may not qualify if:

• Patients with eye trauma
• Patients with either arteritic or non arteritic central retinal artery occlusion

Sponsors & Collaborators

• Inas Ahmed Sayed Ammar: lead

Study Sites (1)

Cairo university Kas AL- Ainy Fuculty of medicine

Cairo, Cairo Governorate, 12613, Egypt

Location

MeSH Terms

Conditions

Intracranial Hypertension

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Mahmoud Saad Abd Al-Latif Nwar, Lecturer

  Cairo University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of intensive care unit

Study Record Dates

• First Submitted: March 3, 2023
• First Posted: June 7, 2023
• Study Start: October 15, 2023
• Primary Completion: October 15, 2025
• Study Completion: October 15, 2025
• Last Updated: March 19, 2026

Record last verified: 2023-11

Locations

EG (1)