Influence and Relationships Between Square-stepping Exercise and Brain Activation, Cognitive Function, Physical Performance in Healthy Older Adults

NCT05891574 | Completed

• 1 other identifier: NYCU112078AE
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Background and purposes: Square-stepping exercise (SSE) has been proved to be an effective intervention for motor and cognitive function in older adults. However, the underlying mechanism of SSE still remains undetermined. Therefore, the aim of this study is to elucidate the possible mechanism of SSE in healthy older adults. Methods: This is a cross-sectional study. Inclusion criteria are: (1) age between 65 and 90 years, (2) no frailty indicated by Fried frailty criteria, (3) mini-mental state examination score≧24 and Montreal Cognitive Assessment score≧26, (4) ability to walk independently for 1 min. Brain activation differences between SSE patterns and usual walking, as well as relationships between brain activity, cognitive function, physical performance and SSE performance will be examined. This study will address both cognitive and motor aspects of possible mechanism in SSE. SPSS version 25.0 (SPSS Inc., Chicago, IL, USA) will be used to analyze the collected data in this study. One-way ANOVA with repeated measures is used to evaluate the differences in brain activation among usual walking, SSE-pattern 1, and SSE-pattern 2, with Bonferroni test for post hoc analysis. The Pearson correlation coefficient will be used to establish the relationships between brain activity and SSEs performance, between cognitive function and SSEs performance, and between motor function and SSEs performance. The significant level is set at p\< .05.

Conditions

Older Adults; Age Problem

Keywords

older adults; square-stepping exercise; brain activation

Outcome Measures

Primary Outcomes (1)

• Brain activity

  The brain (bilateral PFC, PMC, SMA) activity indicated by brain oxygenation will be measured by a wearable functional near-infrared spectroscopy system under 3 conditions: usual walking, SSE-pattern 1 (SSE1), and SSE-pattern 2 (SSE2). * Usual walking: participants walk back and forth at their comfortable speed on a 25-m walkway for 1 min. * SSE1: participants perform SSE pattern 1 on the SSE mat at their comfortable speed, and repeat the pattern for 1 min. * SSE2: participants perform SSE pattern 2 on the SSE mat at their comfortable speed, and repeat the pattern for 1 min.

  at the enrollment (1 day)

Secondary Outcomes (8)

• SSE performance

  at the enrollment (1 day)

• Montreal Cognitive Assessment

  at the enrollment (1 day)

• Trail Making Test

  at the enrollment (1 day)

• Stroop Color and Word Test

  at the enrollment (1 day)

• Digit span test

  at the enrollment (1 day)

Study Arms (1)

healthy older adults

* Age between 65 and 90 years * No frailty indicated by Fried frailty criteria * Mini-mental state examination score equals to or more than 24, and Montreal Cognitive Assessment score equals to or more than 26 * Ability to walk independently for 1 min

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy older adults

You may qualify if:

• Age between 65 and 90 years
• No frailty indicated by Fried frailty criteria
• Mini-mental state examination score equals to or more than 24, and Montreal Cognitive Assessment score equals to or more than 26
• Ability to walk independently for 1 min

You may not qualify if:

• Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
• Any unstable physical condition, psychiatric disorder, and other neurological disorder, or diagnosed with learning disability which may affect participating this study

Sponsors & Collaborators

• National Yang Ming Chiao Tung University: lead

Study Sites (1)

National Yang Ming Chiao Tung University

Taipei, 112304, Taiwan

Location

Study Officials

• Ray-Yau Wang

  National Yang Ming Chiao Tung University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 15, 2023
• First Posted: June 7, 2023
• Study Start: June 1, 2023
• Primary Completion: February 28, 2024
• Study Completion: February 28, 2024
• Last Updated: May 25, 2025

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)