Ultrasound Guided Erector Spinae Block Versus Thoracic Para-vertebral Block Versus Quadratus Lamborum Block in Open Renal Surgeries

NCT05890248 | Unknown DMC

• 1 other identifier: Mohamed A Aboelsuod
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Open renal surgeries are associated with substantial postoperative pain, pain relief in patients undergoing this procedure is usually provided either by thoracic epidural analgesia (EA) or by systemic analgesics. EA is a very useful option for the management of postoperative pain in patients undergoing abdominal surgeries, but the risks and contraindications linked to EA like hypotension, headache, nerve damage or infection may limit its use. Systemic analgesics in the form of opioid analgesics may give rise to side effects like nausea ,vomiting , constipation , allergy or drowsiness and often provide insufficient analgesia. Hence, other methods of postoperative pain management are desired. Sensory level target according to the incision site Flank (T9-T11) , Thoraco-abdominal (T7-T12 ) and Trans-abdominal (T6-T10). Ultrasound (US) guided erector spinae plane (ESP) block is one of the interfascial plane blocks that target the dorsal and ventral rami of the spinal nerves. Although there is no sufficient evidence for the spread of local anesthetic to the ventral rami, recent reports demonstrated effective postoperative analgesia after thoracic and lumbar surgeries affecting both the ventral and dorsal rami. Paravertebral block (PVB) is a technique where a local anesthetic is deposited into a space found on both sides of the spine, called the paravertebral space. It is a block with a dermatomal distribution of pain relief depending on the level of the spine at which the block is sited and the quantity and type of deposited local anesthetic. PVB is effective for pain relief in the thoracic, abdominal and limb regions. primary aim was to compare postoperative opioid consumption rates at 24 h. Secondary end points were to compare pain scores and hemodynamic variables.

Conditions

Renal Disease

Outcome Measures

Primary Outcomes (1)

• Total morphine requirements 24 hours postoperatively

  24 hours post operative

Study Arms (4)

Erector spinea block

-ESPB Group (n=12): Received erector spinae plane block.

Procedure: Technique

Thoracic Paravertebral block

TPVB Group (n=12) : Received thoracic paravertebral block.

Procedure: Technique

Control group

Control Group (n=12): Received morphine (0.1 mg/kg iv) before skin incision .

QLB group

Quadratus lamborum block n=12

Procedure: Technique

Interventions

Technique PROCEDURE

Paravertebral block versus Erector spinea block versus quadratus lamborum block

Also known as: Paravertebral block versus Erector spinea block versus quadratus lamborum block

Erector spinea block; QLB group; Thoracic Paravertebral block

Eligibility Criteria

• Age: 21 Years - 65 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This was randomized, controlled, single-blinded study, conducted in urology operating theatre, Al-Azhar university hospital. Forty eight patients of both sex and aged from 21-65 years in period between February 2022 to September 2023 scheduled for elective open renal surgeries under general anesthesia were enrolled in this study. The procedure was explained to the patient and informed consent was signed after his agreement then the patient was classified to one of three groups

You may not qualify if:

• Patient's refusal.
• Patients with ASA (III , IV) score.
• Coagulopathy to be cancelled if ( INR\>1.4 , Platelets count \<100x109 )
• Infection at the injection site.
• Allergy to local anesthetics.
• Patients receiving opioids for chronic analgesic therapy

Sponsors & Collaborators

• mohamed A Aboelsuod, MD: lead

Study Sites (1)

Azhar University

Cairo, 11765, Egypt

RECRUITING

MeSH Terms

Conditions

Kidney Diseases

Interventions

Methods

Condition Hierarchy (Ancestors)

Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Investigative Techniques

Central Study Contacts

mohamed Aboelsuod, MD

CONTACT

00201091945931; abosoad.mohamed2017@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: assisstant professor

Study Record Dates

• First Submitted: May 14, 2023
• First Posted: June 6, 2023
• Study Start: February 1, 2023
• Primary Completion: January 1, 2024
• Study Completion: February 1, 2024
• Last Updated: June 8, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)