Optimal Timing for Resistance Exercise in Hemodialysis

NCT05889130 | Completed

• 1 other identifier: 2023-86766
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 2

Brief Summary

The study consists of two groups doing resistance exercise for the first and last two hours of the HD session. The investigators are planning to form the sample size of exercise training from 40 participants, which the investigators determined according to the power analysis the investigators have done based on the blood pressure outcome criterion. Participants who meet the inclusion criteria the investigators have set will be divided into two groups. A resistance exercise training will be given three days a week for eight weeks, with a total of 24 sessions. The number of IRCAs occurring in both groups and blood pressure values to be measured at the beginning and end of the HD session will be checked, and both parameters will be compared between the groups before and after the treatment after 8 weeks of training. Thus, the investigators aim to show how the time factor has an effect on blood pressure. In addition, muscle strength, physical performance and quality of life of participants before and after resistance exercise will be evaluated and compared between groups. The participants' blood pressure will be evaluated with a conventional cuffed sphygmomanometer, muscle strength, digital hand dynamometer, physical performance, Short Physical Performance Battery and Timed Up and Go Test, and their quality of life will be evaluated with the Kidney Disease Quality of Life-36 (KDQOL-36) quality of life questionnaire. In exercise training, sandbags will be used as resistance. In our study, which the investigators planned as a randomized controlled trial, stratified randomization method will be used to distribute the gender factor homogeneously in both groups.

Conditions

Hemodialysis

Keywords

Hemodialysis; Resistant exercise; Blood Presure; Physical Performance; Quality of Life

Outcome Measures

Primary Outcomes (1)

• systolic and diastolic blood pressure will be measured

  Change from baseline and 8 weeks systolic and diastolic blood pressure

Secondary Outcomes (2)

• The Short Physical Performance Battery Scale

  baseline and 8 weeks

• Kidney Disease Quality of Life-36

  baseline and 8 weeks

Study Arms (2)

first two hours of exercise group

ACTIVE COMPARATOR

This is the group that will do resistance exercise in the first two hours of the hemodialysis session.

Other: Resistant Exercise

last two hours of exercise group

ACTIVE COMPARATOR

This is the group that will do resistance exercise in the last two hours of the hemodialysis session.

Other: Resistant Exercise

Interventions

Resistant Exercise OTHER

The exercises were planned to be performed in 3 sets, 10 repetitions in each set, with 3 minutes rest between sets. Before starting the main exercises, it was planned to do 1 set of the same exercises without weight as a warm-up and cool-down exercise. Exercises were planned as lower extremity hip abduction, adduction, flexion and extension, straight leg raise, terminal knee extension, ankle flexion and bridge exercises. During the exercises, it was planned to be combined with breathing, paying attention to respiratory control.

first two hours of exercise group; last two hours of exercise group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Have been on HD treatment for at least 6 months
• To be receiving HD treatment for 4 hours 3 days a week
• to 90 years old

You may not qualify if:

• Having angina pectoris or uncontrolled arrhythmia and uncontrolled hypertension
• Having communication or cognitive problems at a level that cannot fulfill the requirements of the tests
• Having an orthopedic problem that cannot do the exercise
• Have upcoming travel or kidney transplant plans
• Having an intradialytic hypotensive attack in 3 consecutive sessions

Sponsors & Collaborators

• Muş Alparslan University: lead

Study Sites (2)

Mus Alparslan University

Muş, Güzeltepe District, 49100, Turkey (Türkiye)

Location

Marmara University

Istanbul, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: May 16, 2023
• First Posted: June 5, 2023
• Study Start: May 13, 2023
• Primary Completion: October 7, 2023
• Study Completion: December 30, 2023
• Last Updated: September 29, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (2)