Community Preparedness for Outbreak Response and Readiness for Ebola Vaccination in Liberia
1 other identifier
observational
1,500
1 country
1
Brief Summary
This community-based mixed methods study intends to identify, explore, and assess the determinants of community preparedness for outbreak situations, including acceptance for Ebola vaccines.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2023
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 27, 2023
CompletedStudy Start
First participant enrolled
June 1, 2023
CompletedFirst Posted
Study publicly available on registry
June 5, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2025
CompletedJune 5, 2023
May 1, 2023
1.9 years
April 27, 2023
May 24, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Measure #1
Assess Community Preparedness with the Resiliency Scale
2 Years
Measure #2
Assess Community Acceptance of EVD Vaccine with the Resiliency Scale
2 Years
Secondary Outcomes (2)
Measure #3
2 Years
Measure #4
2 Years
Study Arms (4)
Cluster 1
Communities highly affected and impacted by EVD
Cluster 2
Communities not highly affected and impacted by EVD
Cluster 3
Communities receptive to EVD vaccination
Cluster 4
Communities resistance to EVD vaccination
Interventions
Assessment of the determinants for community preparedness to EVD outbreaks and acceptance of EVD vaccines.
Eligibility Criteria
Health adults (males and females)
You may qualify if:
- Adults
- Community Leaders
- Community Members
- Reside in 1 of 3 highly prevalent counties
- Participated actively in EVD outbreaks related activities
- Documented roles recognized by the Incident Management System
You may not qualify if:
- Not Adults
- Does not reside in any of the 3 highly prevalent counties
- Did not actively participate in the EVD outbreak response related activities
- Roles not documented by the Incident Management System
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Montserrado, Margibi and Lofa Counties
Monrovia, Montserrado County, 1000, Liberia
Related Publications (10)
Kennedy SB, Neaton JD, Lane HC, Kieh MW, Massaquoi MB, Touchette NA, Nason MC, Follmann DA, Boley FK, Johnson MP, Larson G, Kateh FN, Nyenswah TG. Implementation of an Ebola virus disease vaccine clinical trial during the Ebola epidemic in Liberia: Design, procedures, and challenges. Clin Trials. 2016 Feb;13(1):49-56. doi: 10.1177/1740774515621037. Epub 2016 Jan 14.
PMID: 26768572RESULTNyenswah T, Fallah M, Sieh S, Kollie K, Badio M, Gray A, Dilah P, Shannon M, Duwor S, Ihekweazu C, Cordier-Lassalle T, Shinde SA, Hamblion E, Davies-Wayne G, Ratnesh M, Dye C, Yoder JS, McElroy P, Hoots B, Christie A, Vertefeuille J, Olsen SJ, Laney AS, Neal JJ, Yaemsiri S, Navin TR, Coulter S, Pordell P, Lo T, Kinkade C, Mahoney F; Centers for Disease Control and Prevention (CDC). Controlling the last known cluster of Ebola virus disease - Liberia, January-February 2015. MMWR Morb Mortal Wkly Rep. 2015 May 15;64(18):500-4.
PMID: 25974635RESULTO'Dowd A. Infectious diseases are spreading more rapidly than ever before, WHO warns. BMJ. 2007 Sep 1;335(7617):418. doi: 10.1136/bmj.39318.516968.DB. No abstract available.
PMID: 17762021RESULTKennedy SB, Nisbett RA. The Ebola epidemic: a transformative moment for global health. Bull World Health Organ. 2015 Jan 1;93(1):2. doi: 10.2471/BLT.14.151068. No abstract available.
PMID: 25558097RESULTFregonese F. Community involvement in biomedical research conducted in the global health context; what can be done to make it really matter? BMC Med Ethics. 2018 Jun 15;19(Suppl 1):44. doi: 10.1186/s12910-018-0283-4.
PMID: 29945597RESULTDickert N, Sugarman J. Ethical goals of community consultation in research. Am J Public Health. 2005 Jul;95(7):1123-7. doi: 10.2105/AJPH.2004.058933. Epub 2005 Jun 16.
PMID: 15983268RESULTWills C, Tyeku V. Community participation is essential in clinical trials. BMJ. 2000 Sep 30;321(7264):833. No abstract available.
PMID: 11009541RESULTEsangbedo DO, Ughasoro MD, Tagbo BN, Olowu A, Anikene C, Iwegbulam CC. Health-Care Workers' Perspectives on Ebola Virus Vaccine: A Focus Group and In-Depth Interview Interventional Study. Am J Trop Med Hyg. 2016 Sep 7;95(3):654-62. doi: 10.4269/ajtmh.16-0206. Epub 2016 Jul 5.
PMID: 27382077RESULTChiam AL, Cheng NWI, Larson H. Community engagement for outbreak preparedness and response in high-income settings: A systematic review. Glob Public Health. 2022 Jul;17(7):1113-1135. doi: 10.1080/17441692.2021.1919734. Epub 2021 May 2.
PMID: 33938368RESULTPREVAIL III Study Group; Sneller MC, Reilly C, Badio M, Bishop RJ, Eghrari AO, Moses SJ, Johnson KL, Gayedyu-Dennis D, Hensley LE, Higgs ES, Nath A, Tuznik K, Varughese J, Jensen KS, Dighero-Kemp B, Neaton JD, Lane HC, Fallah MP. A Longitudinal Study of Ebola Sequelae in Liberia. N Engl J Med. 2019 Mar 7;380(10):924-934. doi: 10.1056/NEJMoa1805435.
PMID: 30855742RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Stephen B Kennedy, MD, MPH
UL-PIRE Africa Center, University of Liberia
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 27, 2023
First Posted
June 5, 2023
Study Start
June 1, 2023
Primary Completion
April 30, 2025
Study Completion
April 30, 2025
Last Updated
June 5, 2023
Record last verified: 2023-05
Data Sharing
- IPD Sharing
- Will not share