Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity
Double Blind Placebo Controlled Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity
1 other identifier
interventional
24
1 country
1
Brief Summary
This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2023
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 21, 2023
CompletedFirst Posted
Study publicly available on registry
May 31, 2023
CompletedStudy Start
First participant enrolled
July 24, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedJuly 25, 2023
July 1, 2023
2 months
May 21, 2023
July 24, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Skin Hydration
Skin hydration measured with a non-invasive device, SkinMoistureMeterSC
8 weeks
Skin elasticity
Skin elasticity measured with a non-invasive device, Skin Elastimeter
8 weeks
Secondary Outcomes (2)
Facial pigmentation
8 weeks
Facial redness
8 weeks
Study Arms (2)
Astaxanthin
EXPERIMENTAL6 mg daily
Placebo
PLACEBO COMPARATORInterventions
Astaxanthin at 6 mg is given for daily ingestion and compared against placebo.
Eligibility Criteria
You may qualify if:
- Females who are 30 to 55 years of age
- Half of the women will have Fitzpatrick skin type 1-3 and the other half of the women will have Fitzpatrick skin type 4-6
You may not qualify if:
- Individuals with a known allergy to astaxanthin or other carotenoids (such as zeaxanthin, lutein, lycopene).
- Individuals who are unwilling to discontinue carotenoid supplementation for at least 1 month prior to enrollment
- Individuals unwilling to restrict intake of foods like shrimp, salmon, mangos, carrots, and tomatoes during the study.
- New supplementation within 4 weeks with tocopherol
- Individuals who are unwilling to stay consistent with a facial cleansing regimen.
- Those who are unwilling to discontinue topical hydroquinone, retinoid or benzoyl peroxide for 2 weeks prior to enrollment
- Individuals who are pregnant or breastfeeding.
- Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.
- Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Integrative Skin Science and Researchlead
- AstaRealcollaborator
Study Sites (1)
Integrative Skin Science and Research
Sacramento, California, 95819, United States
MeSH Terms
Interventions
Study Officials
- PRINCIPAL INVESTIGATOR
Raja Sivamani, MD
Integrative Skin Science and Research
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
May 21, 2023
First Posted
May 31, 2023
Study Start
July 24, 2023
Primary Completion
September 30, 2023
Study Completion
December 31, 2023
Last Updated
July 25, 2023
Record last verified: 2023-07
Data Sharing
- IPD Sharing
- Will not share