Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women

NCT05880186 | Completed

• 1 other identifier: UFVitoria_2
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

Caffeine is a natural stimulant with well-recognized metabolic benefits, however, there is a lack of studies investigating the time-of-day caffeine influence to enhance fat oxidation in women. The aim of this study was to evaluate the influence of the time of the day on the effect of caffeine on maximal rate of fat oxidation during aerobic exercise in women.

Conditions

Dietary Supplement

Outcome Measures

Primary Outcomes (1)

• MFO

  Maximal fat oxidation during exercise

  2-months

Secondary Outcomes (3)

• FATmax

  2-months

• RPE

  2-months

• FAT AND CHO oxidation

  2-months

Study Arms (2)

Caffeine intake

EXPERIMENTAL

Test in the morning A dose of 3 mg/kg of caffeine (Bulk Powders, Essex, United Kingdom) was ingested before the beginning of each test. Test in the evening A dose of 3 mg/kg of caffeine (Bulk Powders, Essex, United Kingdom) was ingested before the beginning of each test.

Dietary Supplement: Acute caffeine supplementation

Placebo intake

PLACEBO COMPARATOR

Test in the morning A dose of 3 mg/kg of placebo (Cellulose, Guinama, Valencia, Spain) was ingested before the beginning of each test. Test in the evening A dose of 3 mg/kg of placebo (Cellulose, Guinama, Valencia, Spain) was ingested before the beginning of each test

Dietary Supplement: Acute caffeine supplementation

Interventions

Acute caffeine supplementation DIETARY_SUPPLEMENT

To evaluate the influence of the time of the day (i.e., morning vs evening) on the effect of caffeine on maximal fat oxidation in women.

Caffeine intake; Placebo intake

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• To be non-smokers.
• To have low caffeine intake (i.e., \< 50 mg of caffeine per day in the previous 2 months)
• To show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months.
• To have a regular duration of their menstrual cycle for the previous 6 months.
• To confirm no existence of any type of menstrual disorders such as dysmenorrhea, amenorrhea, or strong symptoms associated with pre-menstrual syndrome.

Sponsors & Collaborators

• Universidad Francisco de Vitoria: lead
• Universidad de Granada: collaborator
• Universidad Rey Juan Carlos: collaborator
• Camilo Jose Cela University: collaborator

Study Sites (1)

Universidad Francisco de Vitoria

Pozuelo de Alarcón, Madrid, 28223, Spain

Location

Related Publications (1)

• Munoz A, Aguilar-Navarro M, Ruiz-Moreno C, Varillas-Delgado D, Amaro-Gahete FJ, Gutierrez-Hellin J, Del Coso J, Lopez-Samanes A. Influence of the time of day in the effect of caffeine on maximal fat oxidation during exercise in women: a randomized, crossover, double-blind, and placebo-controlled study. Eur J Appl Physiol. 2024 Mar;124(3):849-859. doi: 10.1007/s00421-023-05312-2. Epub 2023 Sep 20.

  PMID: 37728787 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Dietary Supplement: caffeine acute supplementation

Study Record Dates

• First Submitted: May 18, 2023
• First Posted: May 30, 2023
• Study Start: February 9, 2021
• Primary Completion: April 9, 2021
• Study Completion: April 9, 2021
• Last Updated: May 30, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)