Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief
Adapting Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief: The MORE Relief Trial
1 other identifier
interventional
76
1 country
1
Brief Summary
The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2 chronic-pain
Started May 2023
Longer than P75 for phase_2 chronic-pain
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 16, 2023
CompletedFirst Submitted
Initial submission to the registry
May 17, 2023
CompletedFirst Posted
Study publicly available on registry
May 26, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 16, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 16, 2027
September 23, 2025
September 1, 2025
4 years
May 17, 2023
September 22, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Rate of participant enrollment to the study
Feasibility of the intervention will be determined by Rate of participant enrollment to the study
12 months
Study Arms (4)
Wait List Control (WLC) Usual Care Procedure
PLACEBO COMPARATORParticipants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers.
16-hour MORE treatments
EXPERIMENTALPatients in the 16-hour MORE format will receive one 2hrs treatment a week for 8 consecutive weeks (as per study schema: from week 1 to week 8).
8-hour MORE treatments
EXPERIMENTALPatients in the 8-hour MORE format will receive one 2hrs treatment a week for 4 consecutive weeks (as per study schema: from week 1 to week 4).
2-hour MORE treatments
EXPERIMENTALPatients in the 2-hour MORE format will receive one 2hrs treatment (as per study schema: in week 1).
Interventions
MORE participants will also be asked to engage in 15 minutes/day of skill practice at home, and complete daily diaries of mindfulness practice time
Participants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers.
Eligibility Criteria
You may qualify if:
- English speaking
- Age ≥ 18 years or older
- A history of cancer with no restrictions placed on type of cancer
- Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers
- Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
- Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days
- Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC
- Ability to attend video-call session and a quiet/private location
You may not qualify if:
- Active suicidality or schizophrenia
- Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks
- Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065, United States
Related Publications (1)
Bryl KL, Hanley AW, Baser RE, Desai K, Dowd M, Li Q, Sandweiss B, Garland EL, Mao JJ. Mindfulness-Oriented Recovery Enhancement for Cancer Pain Relief: Pilot Randomized Controlled Trial. J Pain Symptom Manage. 2026 Jan 3:S0885-3924(25)01035-8. doi: 10.1016/j.jpainsymman.2025.12.024. Online ahead of print.
PMID: 41490669DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jun Mao, MD, MSCE
Memorial Sloan Kettering Cancer Center
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 17, 2023
First Posted
May 26, 2023
Study Start
May 16, 2023
Primary Completion (Estimated)
May 16, 2027
Study Completion (Estimated)
May 16, 2027
Last Updated
September 23, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will share
Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.