Effects of Left Nostril Breathing in Young Females Having Cardiovascular Hyper Reactivity to Cold Pressor Test.

NCT05876637 | Completed DMC

• 1 other identifier: Muqaddas Bibi
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effects of left nostril breathing in young females having cardiovascular hyper reactivity to cold pressor test.Although,limited literature exist regarding hyper reactivity towards stress induced test in our youth and its effective and easy treatment in the form of left nostril breathing which could proves to be beneficial for our youth.

Conditions

Healthy

Keywords

blood pressure; cold pressor test; heart rate

Outcome Measures

Primary Outcomes (3)

• Cold pressor test

  Cold pressor test will be conducted on participants to measure cardio vascular hyper reactivity to stress induce test.

  After 4 weeks

• Blood pressure

  Mercury sphygmomanometer will be used to measure blood pressure of participants

  After 4 weeks

• Heart Rate

  Pulse oximeter will be applied to the participant to measure their Heart rate.

  After 4 weeks

Secondary Outcomes (1)

• Oxygen saturation

  after 4 weeks

Study Arms (2)

Left Nostril Breathing

EXPERIMENTAL

The intervention protocol include healthy young females age 18-25 years.. All baseline measurements will be taken , Afterwards, the Cold pressor test would be performed for 1 minutes to induce acute stress while the BP would be monitored for every 30 seconds. At the end of the test, again the BP would be monitored. Out of all the recordings, the BP measuring the highest value would be recorded as final. We will then subtract the normal resting BP by highest value of the recording for each participant. Change in BP of systolic by 25mmHg and diastolic by 20mmHg will be considered hyper reactive. Then the hyper reactive subjects will be divided into two groups. Experimental group will receive left nostril breathing. CPT will be performed again at 4, 8 and 12 weeks to monitor the BP, heart rate and Spo2 likewise to check for any decline in sympathetic activity.

Other: Left Nostril Breathing

Conventional

ACTIVE COMPARATOR

The conventional protocol include healthy young females age 18-25 years. All baseline measurements will be taken, Afterwards, the Cold pressor test would be performed for 1 minutes to induce acute stress while the BP would be monitored for every 30 seconds. At the end of the test, again the BP would be monitored. Out of all the recordings, the BP measuring the highest value would be recorded as final. We will then subtract the normal resting BP by highest value of the recording for each participant. Change in BP of systolic by 25mmHg and diastolic by 20mmHg will be considered hyper reactive. Then the hyper reactive subjects will be divided into two groups Group A(Experimental) and Group B(Conventional). Controlled group will receive simple deep breathing exercises ,3 sessions per week for 12 weeks. CPT will be performed again at 4, 8 and 12 weeks to monitor the BP, heart rate and Spo2 likewise to check for any decline in sympathetic activity.

Other: Conventional

Interventions

Left Nostril Breathing OTHER

The participants which will show cardiovascular hyper reactivity towards CPT will be divided into 2 groups having 30 participants in each group. Experimental group will receive Left Nostril Breathing(slow, deep breath taken through your left nostril while closing your right nostril with your right thumb. Then just as gently exhale long, slowly, and completely through the left nostril, just as gently. It will be done while sitting) for 10 minutes twice a day for the duration of 12 weeks. Follow up will be taken through administration Cold pressor test after every 4,8 and 12 weeks.

Left Nostril Breathing

Conventional OTHER

30 participants will be recruited in conventional group which will receive simple deep breathing exercises of 3 sessions per week for the duration of 12 weeks.Follow up will be taken after every 4,8 and 12 weeks.

Conventional

Eligibility Criteria

• Age: 18 Years - 25 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Participants falling in the following category would be recruited into the study:
• Females Age (18-25) years
• Participants who show hyper reactivity to Cold pressor test (i.e subjects showing 25mmHg increase in systolic blood pressure along with 20mmHg increase in diastolic blood pressure)
• Consenting participants.

You may not qualify if:

• The participants in the following category would be excluded from the study:
• Participants on antihypertensive drugs.
• Participants who are diagnosed with any cardiovascular, renal, hepatic or metabolic disease.
• Participants having malignant tumor.
• Participants with nasal blockages, polyps ,Raynaud phenomena
• Females during menstrual cycle, pregnancy or on oral contraceptives.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Women Instritute of Rehabilitation Sciences, Jinnah College of Nursing

Abbottābād, KPK, 22010, Pakistan

Location

Related Publications (5)

• Shah N, Shah Q, Shah AJ. The burden and high prevalence of hypertension in Pakistani adolescents: a meta-analysis of the published studies. Arch Public Health. 2018 Apr 2;76:20. doi: 10.1186/s13690-018-0265-5. eCollection 2018.

  PMID: 29619218 BACKGROUND

• Malhotra V, Srivastava R, Parasuraman P, Javed D, Wakode S, Thakare A, Sampath A, Kumari A. Immediate autonomic changes during right nostril breathing and left nostril breathing in regular yoga practitioners. J Educ Health Promot. 2022 Aug 25;11:280. doi: 10.4103/jehp.jehp_343_22. eCollection 2022.

  PMID: 36325230 BACKGROUND

• Jain N, Srivastava RD, Singhal A. The effects of right and left nostril breathing on cardiorespiratory and autonomic parameters. Indian J Physiol Pharmacol. 2005 Oct-Dec;49(4):469-74.

  PMID: 16579402 BACKGROUND

• Bargal S, Nalgirkar V, Patil A, Langade D. Evaluation of the Effect of Left Nostril Breathing on Cardiorespiratory Parameters and Reaction Time in Young Healthy Individuals. Cureus. 2022 Feb 18;14(2):e22351. doi: 10.7759/cureus.22351. eCollection 2022 Feb.

  PMID: 35371755 BACKGROUND

• Wood DL, Sheps SG, Elveback LR, Schirger A. Cold pressor test as a predictor of hypertension. Hypertension. 1984 May-Jun;6(3):301-6. doi: 10.1161/01.hyp.6.3.301.

  PMID: 6735451 BACKGROUND

MeSH Terms

Interventions

Congresses as Topic

Intervention Hierarchy (Ancestors)

Organizations; Health Care Economics and Organizations

Study Officials

• Suman Sheraz, PhD*

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 17, 2023
• First Posted: May 25, 2023
• Study Start: September 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: December 15, 2023
• Last Updated: January 30, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)