Effects of Continuous Anterior Chest Compression

NCT05876468 | Completed

• 1 other identifier: APHP211357
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to test the physiological effects of continuous anterior chest compression in patients with severe to moderate ARDS.

Conditions

Evaluable

Keywords

ARDS : Acute Respiratory Distress Syndrome; CACC : Continuous Anterior Chest Compression; VILI : Ventilator-Induced Lung Injury; ARDS,Human: Adult Respiratory Distress Syndrome

Outcome Measures

Primary Outcomes (1)

• The end inspiratory transpulmonary pressure (PL-insp) in centimetre of water

  The transpulmonary pressure will be measured by using an esophageal catheter connected to a differential pressure transducer. The PL-insp will be calculated using the ratio between the elastance of the lung (El) and of the respiratory system (Ers) expressed in centimetre of water thanks to this formula PL-insp = Plateau pressure x (El/Ers). The PL-insp between the different protocol conditions will be compared (After 16 hours of prone position, in supine position, 15mn after CACC with a pressure equal to the one observed in the prone position, 15mn after CACC with a pressure set at 60 - 80 cmH20, 15mn after taking off the CACC in supine position ). CACC will be considered protective if there is a decrease in Pl-insp.

  Through study completion (up to 6 hours)

Secondary Outcomes (8)

• Regional pulmonary compliances in centimetre of water

  Through study completion (up to 6 hours)

• Lung mechanics : Airways pressure, Flow curves and Esophageal pressure

  Through study completion (up to 6 hours)

• Pulmonary ventilation distribution in percentage

  Through study completion (up to 6 hours)

• Recruitment-to-inflation (R/I) ratio

  Through study completion (up to 6 hours)

• Hemodynamics

  Through study completion (up to 6 hours)

Study Arms (1)

A description of each arm of the clinical trial that indicates its role in the clinical trial

EXPERIMENTAL

Arm 1 Description: The study will consitent of recording the measurments of ventilatory settings, respiratory mechanics, flow and pressure curves, gaz exchange, haemodynamics and ventilation distribution in 5 consecutive conditions in adult patients with moderate to severe ARDS : * After 16 hours of prone position * In supine position 1 hour after the prone position * 15mn after CACC with a pressure equal to the one observed in the prone position * 15mn after CACC with a pressure set at 60 - 80 cmH20 * 15mn after taking of the CACC

Device: Continuous anterior chest compression

Interventions

Continuous anterior chest compression DEVICE

Patients with severe to moderate ARDS who were placed in prone position by the attending physician : * First CACC : the applied pressure is equal to the one observed in the prone position * Second CACC : The applied pressure is set at 60 - 80 cmH20

A description of each arm of the clinical trial that indicates its role in the clinical trial

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 ans
• Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio \<= 200 mmHg)
• The patent must be sedated and paralyzed
• Informed consent from patient or family members

You may not qualify if:

• Extracorporeal membrane oxygenation (ECMO)
• Pneumothorax
• Thoracic trauma during the last 3 months
• Refractory shock
• Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
• Pregnancy
• Any contra-indication to esophageal manometry (less than one month esophagus surgery, bronchopleural or esotracheal fistula, latex allergy)
• No social care
• Adults under Guardianship, curatorship or protection of the court

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Assistance Publique Hôpitaux de Paris - CHU HENRI MONDOR

Créteil, 94010, France

Location

MeSH Terms

Conditions

Acute Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Guillaume CARTEAUX, MD, PhD

  APHP

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Clinical trials with a single arm

Study Record Dates

• First Submitted: August 8, 2022
• First Posted: May 25, 2023
• Study Start: April 13, 2022
• Primary Completion: June 25, 2023
• Study Completion: June 25, 2023
• Last Updated: February 11, 2026

Record last verified: 2026-01

Locations

FR (1)