Prosody Assessment After Right Hemisphere Stroke

NCT05874011 | Recruiting

• 1 other identifier: APHP200144
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Following a right stroke, more than half of the patients present a communication disorder. These disorders can notably concern prosody. Nevertheless, these remain relatively poorly assessed and characterized. Prosodic alterations in comprehension can result in a disruption of social cognition with potentially important consequences in terms of functional outcome and quality of life of patients. In clinical practice, the investigators do not have a tool that allows us to finely assess these disorders. Studies in healthy subjects using a processing algorithm capable of arbitrarily manipulating the pitch dynamics of recorded voices have revealed that there are stable internal representations for prosody processing. Initial pilot results show that this method can be used in a clinical context and can indeed identify and accurately measure perceptual processing deficits in prosody following a right stroke. It is necessary to continue the study of this approach with a larger number of subjects in order to have normative data and validate the diagnostic properties of this approach.

Conditions

Right Hemisphere Stroke

Keywords

Prosody; Reverse correlation; Stroke

Outcome Measures

Primary Outcomes (1)

• Evolution of the inverse correlation task at the beginning and at the end of participation

  The inverse correlation task that will be proposed in the study consists of presenting pairs of the word "really" with random variations in the height (F0) of the bounds of the six 71 ms segments of the word, asking them to distinguish within each pair which is the more interrogative.

  6 months

Secondary Outcomes (7)

• Assessment of musical perception

  Inclusion, after 3 months and 6 months

• Assessment of anxiety

  Inclusion, after 3 months and 6 months

• Assessment of depression

  Inclusion, after 3 months and 6 months

• Assessment of auditory attention

  Inclusion, after 3 months and 6 months

• Assessment of central auditory disorders

  Inclusion, after 3 months and 6 months

Study Arms (2)

Patients

Patients with right stroke consecutively recruited according to inclusion and non-inclusion criteria

Other: understanding of prosody

Healthy volunteers

Healthy volunteers with no known history of stroke

Other: understanding of prosody

Interventions

understanding of prosody OTHER

The inverse correlation test consists of having the same word heard twice, and asking which of the two sounds the most like a question. The exercise will be repeated several times, for a task that will take a total of about thirty minutes

Healthy volunteers; Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Major patients with right supratentorial stroke and major control subjects with no known history of stroke will be enrolled in this study.

You may qualify if:

• Patient:
• right-handed
• male and female over 18 years of age
• french mother tongue
• affiliated or beneficiary of a social security plan
• free, informed and written consent signed
• Subject:
• no known history of stroke
• right-handed
• over 18 years of age and matched with a case on age (plus or minus 10 years)
• french mother tongue
• affiliated or beneficiary of a social security plan
• free, informed and written consent signed

You may not qualify if:

• comprehension disorders: score less than 10/15 on the BDAE (Boston Diagnostic Aphasia Examination) command execution test
• known dementia
• illiteracy
• severe dysarthria
• psychiatric history requiring hospitalization in a specialized environment for more than two months
• history of brain injury
• major visual or auditory perceptual disorder (hearing loss greater than 40 dB HL)

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière

Paris, 75013, France

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Marie VILLAIN, Ms.

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Marie VILLAIN, Ms.

CONTACT

(0)6 72 34 60 26; marie.villain@aphp.fr

Anne BISSERY, Ms.

CONTACT

(0)1 42 16 24 32; anne.bissery@aphp.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2023
• First Posted: May 24, 2023
• Study Start: July 12, 2024
• Primary Completion (Estimated): July 12, 2026
• Study Completion (Estimated): January 11, 2027
• Last Updated: January 23, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Beginning 3 months and ending 3 years following article publication. Requests out of these time frame can also be submitted to the sponsor
• Access Criteria: Researchers who provide a methodologically sound proposal.

Locations

FR (1)