NCT05871606|RecruitingPhase 1DMCFDA Drug
Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
iNO
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Sponsor study identifier
interventional
36
1 country
2
Study Start
April 16, 2026
Actual (reported)Primary Completion
August 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute ischemic (non-bleeding) stroke (AIS).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 12, 2023
Actual (reported)May 23, 2023
Actual (reported)April 16, 2026
Actual (reported)August 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Maximum safe dose of iNO for AIS patients - assessing for reperfusion hemorrhage/symptomatic intracranial hemorrhage (sICH)
To establish a maximum safe dose of iNO for acute ischemic (non-bleeding) stroke (AIS) patients, assessing for reperfusion hemorrhage/symptomatic intracranial hemorrhage (sICH)
Year 2
Change in pre-endovascular mechanical thrombectomy (IAMT) and post-IAMT core infarct volume
Year 2
Dose 2- Inhaled Nitrous Oxide (iNO) 40ppm.
Dose 3- Inhaled Nitrous Oxide (iNO) 50ppm.
Dose 4- Inhaled Nitrous Oxide (iNO) 60ppm.
Inhaled Nitrous Oxide
Carolinas Medical Center
Charlotte, North Carolina, 28203, United States
Atrium Health
Charlotte, North Carolina, 28204, United States
William R Stetler, MD
Wake Forest University Health Sciences
First Submitted
May 12, 2023
First Posted
May 23, 2023
Can Nitrous Oxide (Laughing Gas) be Used as a Sedative for GI Endoscopy Procedures?
Dose 5- Inhaled Nitrous Oxide (iNO) 70ppm.
Dose 6- Inhaled Nitrous Oxide (iNO) 80ppm.
Dose 1- Inhaled Nitrous Oxide (iNO) 20ppm.
Contact the study team to confirm eligibility.
Study Start
April 16, 2026
Actual (reported)Primary Completion
August 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 23, 2026
Record last verified: 2026-04
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Source: ClinicalTrials.gov.
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