Muscle Activation in Knee Osteoarthritis
Gender Difference of Muscle Activation Amongst Patients With Knee Osteoarthritis
1 other identifier
observational
70
1 country
1
Brief Summary
Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA). Many trials investigated muscle activity during dynamic movements and functional tasks in KOA. In addition, gender-related differences has been also investigated during functional movements in KOA. However, no trial investigated gender-related differences in muscle activation during static movement in KOA.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 30, 2023
CompletedFirst Submitted
Initial submission to the registry
May 2, 2023
CompletedFirst Posted
Study publicly available on registry
May 23, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
November 30, 2023
CompletedDecember 1, 2023
November 1, 2023
6 months
May 2, 2023
November 30, 2023
Conditions
Outcome Measures
Primary Outcomes (13)
Patients' baseline state
Measurement of patients' pain, stiffness and functional state based on WOMAC
within 1 day
Patients' baseline pain
Measurement of patients' pain based on Numeric Pain Rating Scale
within 1 day
Patients' baseline knee flexion
Measurement of patients' active knee flexion in supine
within 1 day
Patients' baseline knee flexion in standing position
Measurement of patients' active knee flexion during weight-bearing
within 1 day
Muscle strength of m. quadriceps femoris
Measurement of muscle strength of m. quadriceps femoris in 0, 35 and 60 degree
within 1 day
Muscle strength of hamstring muscles
Measurement of muscle strength of m. semitendinosus, semimembranosus and biceps femoris in 0, 35 and 60 degree
within 1 day
Muscle activation in 30 degree static knee flexion
EMG measurement of muscle activation during 2-leg 30 degree static knee flexion
within 1 day
Muscle activation in 60 degree static knee flexion
EMG measurement of muscle activation during 2-leg 60 degree static knee flexion
within 1 day
Muscle activation during stepping up a stair
EMG measurement of muscle activation during stepping up on a stair
within 1 day
Muscle activation during stepping down a stair
EMG measurement of muscle activation during stepping down from a stair
within 1 day
Muscle activation during stepping down side-ways a stair with affected leg
EMG measurement of muscle activation during stepping down side-ways a stair with affected leg
within 1 day
Muscle activation during stepping down side-ways a stair with opposite leg
EMG measurement of muscle activation during stepping down side-ways a stair with opposite leg
within 1 day
Muscle activation in one-leg standing position
EMG measurement of muscle activation in one-leg standing position
within 1 day
Study Arms (2)
Men group
Muscle activity amongst men with KOA
Women group
Muscle activity amongst women with KOA
Interventions
Electromyography (EMG) measurement of m. quadriceps femoris and semitendinosus muscle during static functional tasks
Eligibility Criteria
Patients with radiologically diagnosed KOA
You may qualify if:
- radiologically diagnosed KOA based on the Kellgren-Lawrence grading system 1-3,
- age above 60 years
- at least 60° active knee flexion
- sufficient mental status
You may not qualify if:
- acute inflammation of the knee
- intraarticular injections within the last 3 months
- total knee replacement in the opposite side
- class II obesity (body mass index, BMI\>35kg/m2)
- severe degenerative lumbar spine disease (e.g., spondylolisthesis)
- systemic inflammatory arthritic or neurological condition
- conservative intervention attendance within 6 months
- contraindication to conservative therapy and manual therapy
- unstable heart condition
- complex regional pain syndrome
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Pécs
Pécs, Baranya, 7621, Hungary
Related Publications (3)
Al Amer HS, Sabbahi MA, Alrowayeh HN, Bryan WJ, Olson SL. Electromyographic activity of quadriceps muscle during sit-to-stand in patients with unilateral knee osteoarthritis. BMC Res Notes. 2018 Jun 5;11(1):356. doi: 10.1186/s13104-018-3464-9.
PMID: 29871669BACKGROUNDBouchouras G, Sofianidis G, Patsika G, Kellis E, Hatzitaki V. Women with knee osteoarthritis increase knee muscle co-contraction to perform stand to sit. Aging Clin Exp Res. 2020 Apr;32(4):655-662. doi: 10.1007/s40520-019-01245-z. Epub 2019 Jun 15.
PMID: 31203528BACKGROUNDSmith SL, Woodburn J, Steultjens MPM. Sex- and osteoarthritis-related differences in muscle co-activation during weight-bearing tasks. Gait Posture. 2020 Jun;79:117-125. doi: 10.1016/j.gaitpost.2020.04.019. Epub 2020 Apr 27.
PMID: 32402893BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Csaba Melczer, Physiother.
University of Pecs
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 2, 2023
First Posted
May 23, 2023
Study Start
April 30, 2023
Primary Completion
November 1, 2023
Study Completion
November 30, 2023
Last Updated
December 1, 2023
Record last verified: 2023-11