The Effects Of Low Intensity Training With Blood Flow Restriction In Rheumatoid Arthritis Patients

NCT05869370 | Unknown

• 1 other identifier: 2018-0071
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Rheumatoid arthritis (RA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in physical function. On the other hand, high intensity resistance training (HIRT) are able to improve muscle strength and muscle mass in RA without affecting the disease course. However, due to the articular manifestations caused by this disease, these patients may present intolerance to HIRT. Thus, the low intensity resistance training with blood flow restriction (TBFR) may be a new training strategy for these populations. In this sense, the investigators speculate that TBFR could be beneficial in RA patients, as well as, HIRT.

Conditions

Rheumatoid Arthritis

Keywords

Rheumatoid Arthritis; Kaatsu; Blood Flow Restriction Training

Outcome Measures

Primary Outcomes (1)

• Muscle strength

  1 maximum repetition test.

  Twelve weeks

Study Arms (2)

High intensity resistance training

EXPERIMENTAL

Other: High intensity resistance training

Low intensity resistance training combined with blood flow restriction

EXPERIMENTAL

Other: Low intensity resistance training combined with blood flow restriction

Interventions

High intensity resistance training OTHER

Twelve weeks of resistance training twice a week.

High intensity resistance training

Low intensity resistance training combined with blood flow restriction OTHER

Twelve weeks of resistance training with blood flow restriction twice a week.

Low intensity resistance training combined with blood flow restriction

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female;
• Rheumatoid arthritis patients;
• All individuals will undergo an ergospirometry to ensure cardiorespiratory conditions.

You may not qualify if:

• Fibromyalgia;
• Cardiovascular disease;

Sponsors & Collaborators

• Federal University of Rio Grande do Sul: lead
• Hospital de Clínicas de Porto Alegre: collaborator

Study Sites (1)

Universidade Federal do Rio Grande do Sul - Faculdade de Medicina - Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

RECRUITING

Related Publications (1)

• Dos Santos LP, Santo RCDE, Ramis TR, Portes JKS, Chakr RMDS, Xavier RM. The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis. PLoS One. 2021 Nov 10;16(11):e0259574. doi: 10.1371/journal.pone.0259574. eCollection 2021.

  PMID: 34758045 BACKGROUND

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: May 11, 2023
• First Posted: May 22, 2023
• Study Start: May 20, 2018
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: May 22, 2023

Record last verified: 2023-05

Locations

BR (1)