The Mental Health Experiences of Sexual and Gender Minorities Living With Cancer and Their Care Partners

NCT05866705 | Completed

• 2 other identifiers: IRB-300009168PREP Award
• Study Type: observational
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine relationships between contextual stressors and stress moderators, depression symptom experience, resilience, frailty, and quality of life among older sexual gender minorities cancer survivors and their care partners.

Conditions

Depression; Anxiety; Caregiver Burden; Stress; Chronic Illness

Keywords

cancer; mental health; LGBTQIA+

Outcome Measures

Primary Outcomes (4)

• Daily Depression Symptom Experience

  PROMIS Emotional Distress-Depression Short Form, a 4-item scale measuring common symptoms associated with depresison.

  28 days

• Daily Anxiety Symptom Experience

  PROMIS Emotional Distress-Anxiety Short Form, a 4-item scale measuring common symptoms associated with anxiety.

  28 days

• Depression

  PHQ-9, a 9-item scale for screening, diagnosing, monitoring and measuring the severity of depression.

  28 days

• Anxiety

  GAD-7, a 7-item scale for screening, diagnosing, monitoring and measuring the severity of anxiety.

  28 days

Secondary Outcomes (3)

• Reslience

  28 days

• Health Related Quality of Life

  28 days

• Fraility

  28 days

Study Arms (2)

Cancer

Individuals living with cancer

Care Partner

Care partner for someone who is living with cancer

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

LGBTQIA+ Individuals living with cancer (aged 55+) and their care partners (aged 21+)

You may qualify if:

• Individual living with cancer: 1) self-identifies as a sexual and/or gender minority; 2) ≥55 years of age; 3) diagnosed with cancer (stages 1 through 4), including brain, lung, breast, gynecologic, head and neck, gastrointestinal, genitourinary cancer, melanoma; and hematologic malignancies.
• Care Partner: 1) ≥21 years of age; 2) self-identifies as a care partner of a sexual and/or gender minority diagnosed with cancer (stages 1 through 4), including brain, lung, breast, gynecologic, head and neck, gastrointestinal, genitourinary cancer, melanoma; and hematologic malignancies.

You may not qualify if:

• Individual living with cancer: 1) Medical documentation of active severe mental illness (i.e., schizophrenia, bipolar disorder, or major depressive disorder), dementia, suicidal ideation, uncorrected hearing loss, or substance abuse; 2) does not have reliable internet access.
• Care Partner: 1) Self-reported mental illness (i.e., schizophrenia, bipolar disorder, or major depressive disorder), dementia, active suicidal ideation, uncorrected hearing loss, or active substance abuse; 2) does not have reliable internet access.

Sponsors & Collaborators

• University of Alabama at Birmingham: lead

Study Sites (1)

University of Alabama at Birmingham School of Nursing

Birmingham, Alabama, 35233-1342, United States

Location

MeSH Terms

Conditions

Depression; Anxiety Disorders; Caregiver Burden; Chronic Disease; Neoplasms; Psychological Well-Being

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mental Disorders; Stress, Psychological; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Personal Satisfaction

Study Officials

• Frank Puga

  University of Alabama at Birmingham School of Nursing

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 10, 2023
• First Posted: May 19, 2023
• Study Start: April 3, 2023
• Primary Completion: June 15, 2024
• Study Completion: August 27, 2024
• Last Updated: June 25, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)