Pain Trajectories and Predictors After Noncardiac Surgery in Elderly Patients

NCT05865366 | Completed DMC

• 1 other identifier: TJ-IRB202303136
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study will use group-based trajectory modeling to identify the different postoperative pain trajectory groups that exist in a mixed surgical population (non-cardiac surgery) of elderly patients during the first seven days after surgery. The aim of this study is to explore the diversity in the development of postoperative pain among elderly patients and to identify the risk factors for acute pain trajectory after surgery by investigating demographic, psychological, and clinical variables. The predictive effect of different trajectories of early postoperative acute pain on postoperative chronic pain will also be explored.

Conditions

Acute Postoperative Pain; Trajectory

Keywords

acute postoperative pain, pain trajectory, chronic pain, elderly patient

Outcome Measures

Primary Outcomes (3)

• Acute pain trajectories after surgery

  The acute pain trajectories are vectors of 7 numerical pain scores (ranging from 0 ,which indicates "no pain," to 10 , which indicates "pain as bad as you can imagine") taken over 7 days (days 1, 2, 3, 4, 5, 6, 7).

  Seven days after surgery.

• Presence of pain 3 months after surgery assessed using the Brief Pain Inventory.

  Yes/No

  3 months after surgery

• Presence of pain 6 months after surgery assessed using the Brief Pain Inventory.

  Yes/No

  6 months after surgery

Secondary Outcomes (9)

• consumption of analgesic drugs

  Seven days after surgery

• cumulative illness rating scale for geriatrics，CIR S-G

  day1 before surgery

• The FRAIL Scale(Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index，FRAIL)

  day1 before surgery

• The douleur neuropathique 4 questionnaire(DN4)

  day1 before surgery

• Mini-cog

  day1 before surgery

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

elderly patients scheduled for thoracic, urologic, gastrointestinal, gynecological, liver, biliary/pancreatic, and major orthopedic surgeries under general anesthesia

You may qualify if:

• Scheduled for thoracic, urologic, gastrointestinal, gynecological, liver, biliary/pancreatic, or major orthopedic surgery under general anesthesia
• Age ≥ 65 years
• The American Society of Anaesthesiologists(ASA) I to III
• Duration of hospitalization ≥ 72 hours

You may not qualify if:

• Language disorder;
• Hearing impairment;
• Visual impairment;
• The expected postoperative intubation time is more than 24 hours;
• Critical events occurred during the perioperative period.

Sponsors & Collaborators

• Feng Gao: lead

Study Sites (1)

Tongji Hospital

Wuhan, Hubei, 430030, China

Location

MeSH Terms

Conditions

Pain, Postoperative; Chronic Pain

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 22, 2023
• First Posted: May 18, 2023
• Study Start: June 1, 2023
• Primary Completion: December 25, 2023
• Study Completion: June 26, 2024
• Last Updated: November 19, 2025

Record last verified: 2025-11

Locations

CN (1)