Preoperative Versus Postoperative Quadratous Lunborum Block in Nephrectomy

NCT05860309 | Unknown

• 1 other identifier: MS 183/2023
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

A multimodal analgesia regimen is suggested after nephrectomy, although some patients still report agonising pain. Regional anesthesia approaches may improve postoperative pain management and reduce the requirement for opioids after renal surgery.QLB provides early and rapid pain relief

Conditions

Regional Blocks; Renal Surgery

Keywords

multimodal analgesia, regional blocks, renal surgeries

Outcome Measures

Primary Outcomes (1)

• The time to first postoperative rescue analgesia.

  the first time patient ask for analgesia

  postoperative 24 hours

Secondary Outcomes (1)

• total consumption of opioid in first 24 hours

  first 24 hours postoperatively

Study Arms (2)

preoperative quadratous lumborum block

ACTIVE COMPARATOR

patients weill recieve preoperative ultrasound guided quadratous lumborum block at lateral position before start of surgery after induction of general anesthesia

Other: quadratous lumborum block

postoperative quadratous lumborum block

ACTIVE COMPARATOR

patients weill recieve postoperative ultrasound guided quadratous lumborum block at lateral position at the end of surgery before recovery from general anesthesua

Other: quadratous lumborum block

Interventions

quadratous lumborum block OTHER

The patient will be placed in the lateral position, after sterilization.. QLB will be done using ultrasound, The probe will be positioned superior to the iliac crest, in the transverse orientation, at the posterior axillary line. The Shamrock sign will be identified at the L4 level, and the insulated nerve block needle will be advanced from posterior to anterior, through the QL muscle, until the needle tip is visualized in the interfascial plane between the QL muscle and psoas muscle. As the correct needle placement is confirmed with 2-3 mL of saline, 20 mL of 0.25% bupivacaine will be injected ensuring that the psoas muscle will be pushed deeply.

Also known as: myofascial block

postoperative quadratous lumborum block; preoperative quadratous lumborum block

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• o Patients aged between 18 - 60 years old.
• Both sexes.
• Physical Status: ASA I and II.

You may not qualify if:

• o Refusal of procedure or participation in the study .
• Physical status: ASA III or above .
• Infection at site of injection.
• Psychiatric illness .
• CNS Diseases like epilepsy, stroke …etc.
• History or evidence of coagulopathy .
• Allergies to drug used (Bupivacaine 0.5%).
• Patients who suffered from allergy to local anesthetics .
• Difficult visualization of the anatomy.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ainshams hospitals

Cairo, 11591, Egypt

Location

Related Publications (1)

• Borys M, Szajowska P, Jednakiewicz M, Wita G, Czarnik T, Mieszkowski M, Tuyakov B, Galkin P, Rahnama-Hezavah M, Czuczwar M, Piwowarczyk P. Quadratus Lumborum Block Reduces Postoperative Opioid Consumption and Decreases Persistent Postoperative Pain Severity in Patients Undergoing Both Open and Laparoscopic Nephrectomies-A Randomized Controlled Trial. J Clin Med. 2021 Aug 15;10(16):3590. doi: 10.3390/jcm10163590.

  PMID: 34441884 BACKGROUND

Study Officials

• sanaa F wasfy

  Ain Shams University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

sanaa F wasfy

CONTACT

01061262757; sanaawasfy@gmail.com

Wael S Abdelmegied

CONTACT

01282269727; sanaawasfy@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor of anesthesia and intensive care

Model Details: preoperative versus postoperative quadratous lumborum block in nephrectomy

Study Record Dates

• First Submitted: May 6, 2023
• First Posted: May 16, 2023
• Study Start: June 1, 2023
• Primary Completion: November 1, 2023
• Study Completion: December 1, 2023
• Last Updated: May 16, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)