Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp

NCT05859646 | Completed

• 1 other identifier: D-KA 19/41
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.

Conditions

Tooth Decay; Probiotics; Streptococcus Mutans

Keywords

tooth caries; probiotics; qPCR; Streptococcus mutans; Lactobacillus

Outcome Measures

Primary Outcomes (2)

• S mutans count

  CFU

  6 month

• Lactobacillus spp count

  CFU

  6 month

Study Arms (2)

Probiotics

EXPERIMENTAL

Group A-Probiotics group: Patients who started using probiotic drops after general anesthesia procedure

Dietary Supplement: Probiotic use

Control

NO INTERVENTION

Group B-Control group: Patients who did not use any probiotics after general anesthesia procedure

Interventions

Probiotic use DIETARY_SUPPLEMENT

Probiotics were used for 3 months and all participated patients were followed for 6 months.

Also known as: Follow-up after general anesthesia

Probiotics

Eligibility Criteria

• Age: 2 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Every included child had at least 8 tooth with caries.

You may not qualify if:

• Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.

Sponsors & Collaborators

• Didem Sakaryali Uyar: lead

Study Sites (1)

Başkent University

Ankara, Cankaya, 06490, Turkey (Türkiye)

Location

Related Publications (1)

• Sakaryali Uyar D, Uskudar Guclu A, Celik E, Memis Ozgul B, Altay Kocak A, Basustaoglu AC. Evaluation of probiotics' efficiency on cariogenic bacteria: randomized controlled clinical study. BMC Oral Health. 2024 Aug 2;24(1):886. doi: 10.1186/s12903-024-04659-y.

  PMID: 39095860 DERIVED

MeSH Terms

Conditions

Dental Caries

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcome assessment was performed by a different researcher who was unaware of the group distributions in which patients were included.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Asst. Prof. Dr.

Model Details: 2 separate groups, experimental and control, 6 month follow-up period, randomized distribution

Study Record Dates

• First Submitted: May 5, 2023
• First Posted: May 16, 2023
• Study Start: January 15, 2020
• Primary Completion: January 15, 2022
• Study Completion: May 15, 2022
• Last Updated: May 16, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)