First-generation OTC Antihistamine Use and Voice Function: A Preliminary Study

Primary Outcomes (9)

• Urine specific gravity (g/ml)

  Objective measurement of systemic hydration

  Start of trial

• Fundamental frequency (Hertz)

  Sustained "a" task from which the cycles of vocal fold vibration per second are extracted.

  Change from Baseline Fundamental Frequency at 3 hours

• Speaking fundamental frequency (Hertz)

  Standard reading task from which the average cycles per second of vocal fold vibration are extracted.

  Change from Baseline Fundamental Frequency at 3 hours

• Harmonic-to-Noise ratio (decibels, dB)

  Sustained "a" task from which a ratio of the harmonic acoustic components of the signal relative to the noise components of the acoustic signal are determined

  Change from Baseline Fundamental Frequency at 3 hours

• Cepstral peak prominence (decibels, dB)

  An acoustic measurement of voice quality deviation that is extracted from a recorded speech sample.

  Change from Baseline Fundamental Frequency at 3 hours

• Phonation threshold pressure (cm/H20)

  An aerodynamic measurement of the minimum amount of subglottal pressure required to initiate vocal fold vibration for voicing

  Change from Baseline Fundamental Frequency at 3 hours

• Videostroboscopy (video of vocal fold vibration)

  Standard clinical endoscopic imaging of laryngeal structure and function

  Change from Baseline Fundamental Frequency at 3 hours

• OMNI-Vocal Effort Scale (scaled score)

  A validated scale of perceived vocal effort that provides a scale of 1-10 from which to determine how much vocal effort was produced.

  Change from Baseline Fundamental Frequency at 3 hours

• Rating-of-Fatigue (ROF; scaled score)

  A validated scale of perceived voice fatigue

  Change from Baseline Fundamental Frequency at 3 hours