To Investigate the Metabolomics in the Subjects With Long Term Tai Chi Chuan Practice

NCT05854680 | Completed

• 1 other identifier: CHUH108-REC2-020
• Study Type: observational
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

The new biomedical technology including genomics and metabolomics will be applied to the subjects with TCC practice to investigate clinical symptoms and signs expression. The investigators will compare the related molecular pathways especially focusing on immune and inflammation between long term practice and beginner groups.

Conditions

Tai Chi Chuan; Metabolomics

Keywords

Traditional Chinese medicine; Yin and Yang; Tai Chi Chuan; Metabolomics

Outcome Measures

Primary Outcomes (3)

• Serum metabolites

  Collect blood and measure the level of serum metabolites .

  on the day of admission.

• Plasma Cytokines

  Collect blood and measure the level of plasma cytokines. Comparison of cytokine values between different groups.

  on the day of admission.

• Constitution in Chinese Medicine Questionnaire (CCMQ)

  completed on the day of admission.

Secondary Outcomes (4)

• Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale (Version 4)

  completed on the day of admission.

• 36-Item Short Form Health Survey (SF-36)

  completed on the day of admission.

• Pittsburgh Sleep Quality Index (PSQI)

  completed on the day of admission.

• BDI-II score

  completed on the day of admission.

Study Arms (2)

Long term

Tai Chi has been practiced for at least five years, regular practice, at least three times a week, each practice for at least 30 minutes.

Short term

Tai Chi practice time is less than three months, regular practice, at least three times a week, each practice for at least 30 minutes.

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The enrolled normal subjects were confirmed by the Tai Chi Association and the research PI. The long-term group has practiced Tai Chi for at least five years, and the short-term group has been practiced for less than three months. Men and women aged between 20 and 65 are included. We collected all of subjects' basic information, four diagnosis associated with TCM Syndrome Differentiation, FACIT-Fatigue scale, PSQI, BDI-II, SF-36 questionnaire scale, blood tests for CBC, liver and kidney function as well as metabolite analysis.

You may qualify if:

• Adult men and women aged over 20 and under 65.
• Participants agreed to join the trial by fully understanding the purpose of the study and the entire trial process and then signed an informed consent.

You may not qualify if:

• Age of subjects was under 20 or more than 65 years old.
• Subjects were using immunosuppressive or chemotherapy drugs.
• With a history of drug abuse.
• Pregnant or breastfeeding women.
• Mental or behavioral abnormalities such as schizophrenia, depression, suicidal ideation, etc.
• Suffering from serious diseases such as myocardial infarction, heart failure, arrhythmia, chronic respiratory obstructive diseases, cancers, gastrointestinal bleeding (OB positive), etc.
• Subjects with abnormal blood count, abnormal liver function (\>2 times the normal value), and abnormal renal function.
• Subjects were still participating in other clinical trials.
• Subjects were not willing sign the informed consent.

Sponsors & Collaborators

• Sheng-Teng Huang: lead

Study Sites (1)

China Medical University Hospital

Taichung, North District, 404, Taiwan

Location

Study Officials

• Sheng-Teng Huang, MD PhD

  China Medical University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Attending physician

Study Record Dates

• First Submitted: April 19, 2023
• First Posted: May 11, 2023
• Study Start: January 8, 2020
• Primary Completion: July 2, 2021
• Study Completion: December 10, 2021
• Last Updated: May 11, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)