Markers of Metabolism and Vascular Access in ESRD

NCT05854576 | Unknown

• 1 other identifier: mineral metabolism in ESRD
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aim of the study is to determine the association of markers of mineral metabolism with vascular access out come (maturation, patency of vascular access\[AVF,AVG\])To verify the relationship between vascular access complication (AVF,AVG) and lower levels of 25(OH)D, higher levels of fibroblast growth factor 23 (FGF23) and serum calcium, phosphorus, parathyroid hormone (PTH) in patients with ESRD on regular hemodialysis.

Conditions

Disorders of Calcium and Bone Metabolism

Outcome Measures

Primary Outcomes (1)

• association of markers of mineral metabolism with vascular access out come[maturation and patency of vascular access[AVF,AVG]] .To verify the relationship between vascular access complication (AVF,AVG)

  Aim of the study is to determine the association of markers of mineral metabolism with vascular access out come\[maturation, and patency\] .To verify the relationship between vascular access complication (AVF,AVG) and lower levels of 25(OH)D, higher levels of fibroblast growth factor 23 (FGF23) and serum calcium, phosphorus, parathyroid hormone (PTH) in patients with ESRD on regular hemodialysis.

  baseline

Interventions

vascular acess PROCEDURE

AVF

Eligibility Criteria

• Age: 18 Years - 95 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Despite consistent associations of disordered mineral homeostasis and vascular outcomes in ESRD, few studies have investigated the role of these factors in vascular access outcomes. Thes complex interplay of factors may promote vascular disease through multiple pathways including calcification, endothelial dysfunction, inflammation, activation of the renin-angiotensin-aldosterone system and others are involved(15-16),

You may qualify if:

• patient above the age of 18years old.
• patient on regular hemodialysis with vascular access(AVF,AVG)
• patient with Abnormalities in mineral metabolisms.
• Patient secondary, Tertiary hyperparathyroidism.

You may not qualify if:

• patient \<18 years old
• patient with primary hyperparathyroidism

Sponsors & Collaborators

• Soad Elsayed Abu douh: lead

Related Publications (1)

• Gardezi AI, Karim MS, Rosenberg JE, Scialla JJ, Banerjee T, Powe NR, Shafi T, Parekh RS, Yevzlin AS, Astor BC. Markers of mineral metabolism and vascular access complications: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) study. Hemodial Int. 2020 Jan;24(1):43-51. doi: 10.1111/hdi.12798. Epub 2019 Dec 1.

  PMID: 31789482 BACKGROUND

Study Officials

• Eman mohammed

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

soad elsayed

CONTACT

011193711; asoad381@gmail.com

Effat Abdel Hady

CONTACT

01097330309; effattony@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: asoad381@gmail.com

Study Record Dates

• First Submitted: April 8, 2023
• First Posted: May 11, 2023
• Study Start: September 1, 2023
• Primary Completion: September 1, 2024
• Study Completion: November 1, 2024
• Last Updated: May 11, 2023

Record last verified: 2023-05