Clinical and Radiological Prognostic Factors of Acute Necrotizing Encephalopathy in Sohag University Hospital

NCT05853159 | Unknown

• 1 other identifier: Soh-med-23-04-07-MS
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Acute necrotizing encephalopathy of childhood (ANEC) is a fulminant type of encephalopathy. Most reported cases occur in Asian children with the highest prevalence among patients between the age of 6 and 18 months. The most common clinical presentations are fever, rapid alteration in the level of consciousness, and seizures, in addition to characteristic findings in brain imaging that include, but are not limited to, bilateral thalamic lesions with supra and infra-tentorial lesions of variable dimensions. The diagnosis of ANEC was determined by specific diagnostic criteria as described by Mizuguchi \[1\] which consist of

1. 1.Encephalopathy preceded by viral febrile illness with rapid deterioration in the level of consciousness and convulsions.
2. 2.Absent cerebrospinal fluid (CSF) pleocytosis.
3. 3.Symmetric multifocal brain lesions.
4. 4.Elevation in serum aminotransferase levels.
5. 5.Exclusion of similar diseases. The ANE severity score was used to assess the severity of illness after admission for shock (3 points), brainstem lesions (2 points), age \>4 years (2 points), platelet (PLT) count \< 100,000 (1 point), and elevated CSF protein (1 point) was observed. \[3\] A total score of 9

Conditions

Acute Necrotizing Encephalopathy

Outcome Measures

Primary Outcomes (1)

• Acute necrotizing encephalitis severity score

  Clinical and Radiological Prognostic Factors of Acute Necrotizing Encephalopathy in Sohag University Hospital

  one year

Interventions

Basic Laboratory investigations , Cerebrospinal fluid analysis OTHER

to detect severity and prognostic factors of Acute Necrotizing Encephalopathy

Also known as: MRI brain

Eligibility Criteria

• Age: 2 Months - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children aged from 2months up to 12 years admitted to the pediatric emergency department or pediatric ICU presented with Acute encephalopathy \& meet diagnostic criteria of acute necrotizing encephalopathy or come for follow up in our outpatient clinic.

You may qualify if:

• \- Children aged from 2months up to 12 years admitted to the pediatric emergency department or pediatric ICU presented with Acute encephalopathy \& meet diagnostic criteria of acute necrotizing encephalopathy or come for follow up in our outpatient clinic.

You may not qualify if:

• Children known to have metabolic disease. Children who have picture of CNS infection \& confirmed by CSF analysis.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hospital

Sohag, Egypt

Location

Related Publications (4)

• Bashiri FA, Al Johani S, Hamad MH, Kentab AY, Alwadei AH, Hundallah K, Hasan HH, Alshuaibi W, Jad L, Alrifai MT, Hudairi A, Al Sheikh R, Alenizi A, Alharthi NA, Abdelmagid TA, Ba-Armah D, Salih MA, Tabarki B. Acute Necrotizing Encephalopathy of Childhood: A Multicenter Experience in Saudi Arabia. Front Pediatr. 2020 Oct 9;8:526. doi: 10.3389/fped.2020.00526. eCollection 2020.

  PMID: 33163461 BACKGROUND

• Levine JM, Ahsan N, Ho E, Santoro JD. Genetic Acute Necrotizing Encephalopathy Associated with RANBP2: Clinical and Therapeutic Implications in Pediatrics. Mult Scler Relat Disord. 2020 Aug;43:102194. doi: 10.1016/j.msard.2020.102194. Epub 2020 May 15.

  PMID: 32426208 BACKGROUND

• Wu L, Peng H, Jiang Y, He L, Jiang L, Hu Y. Clinical features and imaging manifestations of acute necrotizing encephalopathy in children. Int J Dev Neurosci. 2022 Aug;82(5):447-457. doi: 10.1002/jdn.10201. Epub 2022 Jun 22.

  PMID: 35688614 BACKGROUND

• Song Y, Li S, Xiao W, Shen J, Ma W, Wang Q, Yang H, Liu G, Hong Y, Li P, Yang S. Influenza-Associated Encephalopathy and Acute Necrotizing Encephalopathy in Children: A Retrospective Single-Center Study. Med Sci Monit. 2021 Jan 3;27:e928374. doi: 10.12659/MSM.928374.

  PMID: 33388740 BACKGROUND

MeSH Terms

Conditions

Leukoencephalitis, Acute Hemorrhagic

Condition Hierarchy (Ancestors)

Encephalomyelitis, Acute Disseminated; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Leukoencephalopathies; Brain Diseases; Central Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Marwa M fathy, resident

CONTACT

01033999370; marwamahmoud@med.sohag.edu.eg

Abdelrahim A Sadek, Professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Pediatric and Neonatology Resident at Sohag University Hospital

Study Record Dates

• First Submitted: April 19, 2023
• First Posted: May 10, 2023
• Study Start: May 1, 2023
• Primary Completion: May 1, 2024
• Study Completion: May 1, 2024
• Last Updated: May 10, 2023

Record last verified: 2023-05

Locations

EG (1)