NCT05847582

Brief Summary

Suicide is a high priority public health problem and an increasingly prevalent alcohol-related consequence. One-third of people who die by suicide consume alcohol at hazardous rates in the year preceding death. Most people in an acute suicide crisis who present for treatment are admitted to acute psychiatric hospitalization. Yet, the 30-day period following discharge from hospitalization is by far the riskiest period for another suicide crisis. The specific aim for this project is to evaluate the feasibility and acceptability of an intervention called mHealth-supported Skills Training for Alcohol-Related Suicidality (mSTARS). Thirty-five inpatients with suicidal thoughts or behaviors who misuse alcohol will be randomized to one of three study conditions -- mSTARS, treatment as usual, or treatment as usual with skills training.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
35

participants targeted

Target at P25-P50 for not_applicable

Timeline
17mo left

Started Aug 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 27, 2023

Completed
9 days until next milestone

First Posted

Study publicly available on registry

May 6, 2023

Completed
3.2 years until next milestone

Study Start

First participant enrolled

August 1, 2026

Expected
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2027

2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

March 9, 2026

Status Verified

March 1, 2026

Enrollment Period

1.2 years

First QC Date

April 27, 2023

Last Update Submit

March 5, 2026

Conditions

Outcome Measures

Primary Outcomes (4)

  • Number of participants who are recruited to participate

    This is an indication of feasibility of being able to recruit enough participants in a timely manner into the protocol.

    30 days

  • Number of participants who complete the post-treatment visit

    Retention will be defined as the number of participants who complete the post-treatment visit that occurs 30 days post-discharge.

    30 days

  • Number of participants who rate the intervention a 16 or more on the Client Satisfaction Questionnaire.

    Acceptability of treatment will be measured by an 8-item measure designed to evaluate client satisfaction. Scores range from 8 to 32, with higher scores indicating higher satisfaction.

    30 days

  • Number of participants who score above threshold (34 or more) on the mHealth Satisfaction Questionnaire

    Acceptability of treatment will be measured by a 14-item measure designed to measure usability of mobile health apps. Scores range from 14 to 70. Higher scores indicate higher satisfaction.

    30 days

Secondary Outcomes (16)

  • Average score on the Beck Scale for Suicidal Ideation

    30 days

  • Average score on the Beck Scale for Suicidal Ideation

    3-month follow-up

  • Average number of drinking days

    30 days

  • Average number of drinking days

    3-month follow-up

  • Number of participants who report re-hospitalization to an inpatient psychiatry unit.

    30 days

  • +11 more secondary outcomes

Study Arms (3)

mSTARS

EXPERIMENTAL

Participants randomized to the mSTARS condition will receive standard inpatient care while hospitalized at Duke. They will also receive an intervention that combines inpatient skills training and the mHealth telephone app. Inpatient emotional regulation skills training will be completed while participants are receiving inpatient treatment at Duke. Upon discharge from Duke, patients will download the mHealth app on their personal phones to use in their personal environments for 30 days. The app is designed to encourage participants to apply skills acquired in inpatient skills training to real-life situations.

Behavioral: Standard inpatient psychiatric careBehavioral: Inpatient Skills TrainingBehavioral: mHealth-supported Skills Training for Alcohol-Related Suicidality (mSTARS)

Treatment As Usual

ACTIVE COMPARATOR

Participants randomized to the treatment-as-usual condition will receive standard inpatient care provided at Duke.

Behavioral: Standard inpatient psychiatric care

Treatment As Usual + Skills Training

ACTIVE COMPARATOR

Participants randomized to this condition will receive standard inpatient care and inpatient emotional regulation skills training.

Behavioral: Standard inpatient psychiatric careBehavioral: Inpatient Skills Training

Interventions

All participants involved in this study will receive standard of care treatment at Duke University Medical Center's Behavioral Health Inpatient Program.

Treatment As UsualTreatment As Usual + Skills TrainingmSTARS

Inpatient skills training will be completed while participants are receiving inpatient treatment at BHIP. Skills training includes content designed to improve emotional regulation skills.

Treatment As Usual + Skills TrainingmSTARS

mSTARS includes inpatient skills training and a mobile health (mHealth) telephone app designed to encourage participants to apply skills acquired in inpatient skills training to real-life situations.

mSTARS

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 18+
  • hospitalized for suicide crisis at Duke BHIP
  • an AUDIT-C score indicating hazardous past-month drinking (4 for men; 3 for women) + a 90-day calendar timeline follow-back (TLFB) indicating a minimum of 3 heavy drinking days per week on average (per NIAAA standards)
  • owns a smart phone
  • fluent in English.

You may not qualify if:

  • current psychotic or mania symptoms indicated by the MINI Neuropsychiatric Interview 6.0.(MINI)
  • receiving ECT at the time of hospitalization, which could inhibit learning
  • engaged in weekly outpatient psychotherapy
  • discharging to another high level of psychiatric care.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Alcohol DrinkingSuicide

Interventions

Ethanol

Condition Hierarchy (Ancestors)

Drinking BehaviorBehaviorSelf-Injurious BehaviorBehavioral Symptoms

Intervention Hierarchy (Ancestors)

AlcoholsOrganic Chemicals

Central Study Contacts

Jeremy Grove, PhD

CONTACT

Angela C Kirby, MS

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 27, 2023

First Posted

May 6, 2023

Study Start (Estimated)

August 1, 2026

Primary Completion (Estimated)

October 30, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

March 9, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share