Evaluation of Corticosteroids Use and Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Study

NCT05844410 | Completed DMC

• 1 other identifier: CRU329
• Study Type: observational
• Target: 422
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the recommendations to avoid using corticosteroids systematically for hospitalized coronavirus disease of 2019 (COVID-19) patients, healthcare professionals used personalized treatments, including corticosteroids, as adjuncts to treat their patients due to their limited access to treatment options. This study aims to evaluate the use of corticosteroids among hospitalized COVID-19 patients with all-cause mortality as the primary outcome and to assess the predictors of all-cause mortality associated with the characteristics of the patients and the corticosteroid regimens adopted.

Conditions

COVID-19 Pandemic; Morality

Outcome Measures

Primary Outcomes (1)

• All-cause mortality

  Through study completion, an average of 1 year

Interventions

Corticosteroid DRUG

Adults patients admitted to the hospital after a confirmed COVID-19 infection, irrespective of the stage and severity of the disease, were included in the study. Only those receiving corticosteroids as a treatment were in the study sample, with no preferences based on race or ethnicity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults patients admitted to the hospital after a confirmed COVID-19 infection, irrespective of the stage and severity of the disease, were included in the study.

You may qualify if:

• Adults patients admitted to the hospital after a confirmed COVID-19 infection, irrespective of the stage and severity of the disease, were included in the study.

You may not qualify if:

• Only those receiving corticosteroids as a treatment were in the study sample, with no preferences based on race or ethnicity.

Sponsors & Collaborators

• Lebanese University: lead

Study Sites (1)

Lebanese University Faculty of pharmacy

Beirut, 0000, Lebanon

Location

MeSH Terms

Conditions

COVID-19

Interventions

Adrenal Cortex Hormones

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: May 3, 2023
• First Posted: May 6, 2023
• Study Start: October 20, 2021
• Primary Completion: December 10, 2021
• Study Completion: March 7, 2022
• Last Updated: May 6, 2023

Record last verified: 2023-05

Locations

LE (1)