Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

NCT05843604 | Recruiting

• 1 other identifier: 2022-A00463-40
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Conditions

OCD

Keywords

functional MRI

Outcome Measures

Primary Outcomes (3)

• Cerebral activity modification during N-back task

  Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

  Day 1

• Cerebral activity modification during Stroop task

  Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

  Day 1

• Cerebral activity modification during switching task (Monsell et Mizon task )

  Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

  Day 1

Study Arms (2)

obsessive compulsive disorder patients

Other: Functional MRI

Control Patients

Other: Functional MRI

Interventions

Functional MRI OTHER

Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Control Patients; obsessive compulsive disorder patients

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients will be recruited from the Clinical Research Unit of Poitiers. All volunteer patients included in this study will be included regardless of the degree of resistance to treatment or the severity of their disease. Patients will not be hospitalized for the duration of the study unless their condition requires it. Healthy volunteers will be recruited locally by advertisement or through acquaintances, and will be matched to each patient based on age, gender, laterality, and education level. They must not have an acute pathology being treated, nor take psychotropic drugs, nor be followed in psychotherapy. In their history, we must not find hospitalization in a psychiatric environment or a psychiatric illness according to the M.I.N.I. version 5.0.0.

You may qualify if:

• Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
• Understand and accept the constraints of the study
• Be a beneficiary or affiliated to a Health Insurance scheme

You may not qualify if:

• Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
• Have a serious intercurrent pathology
• Being a pregnant woman
• Being a woman of childbearing age without effective contraception.
• Being hospitalized under duress or on an outpatient basis in a care program
• Being under judicial protection (reinforced curatorship, guardianship)

Sponsors & Collaborators

• Centre Hospitalier Henri Laborit: lead

Study Sites (1)

Centre Hospitalier Henri Laborit

Poitiers, France

RECRUITING

Central Study Contacts

Damien Doolub, MD

CONTACT

+33 (0)5 16 61 18; damien.doolub@ch-poitiers.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 25, 2023
• First Posted: May 6, 2023
• Study Start: July 3, 2023
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: January 13, 2026

Record last verified: 2026-01

Locations

FR (1)