NCT05842538

Brief Summary

The goal of this clinical trial is to compare robotic arm assisted surgery with manual surgery in patients operated with knee replacement. The main aim of the study is to compare changes in joint awareness (measured by the Forgotten Joint Score. Participants who are listed for knee arthroplasty are randomised to either robotic arm assisted surgery or manual surgery.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable knee-osteoarthritis

Timeline
18mo left

Started Apr 2023

Longer than P75 for not_applicable knee-osteoarthritis

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress69%
Apr 2023Nov 2027

First Submitted

Initial submission to the registry

October 3, 2022

Completed
6 months until next milestone

Study Start

First participant enrolled

April 1, 2023

Completed
1 month until next milestone

First Posted

Study publicly available on registry

May 6, 2023

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2025

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2027

Expected
Last Updated

October 10, 2023

Status Verified

October 1, 2023

Enrollment Period

2.6 years

First QC Date

October 3, 2022

Last Update Submit

October 9, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Forgotten Joint Score

    Patient-reported outcome

    1 year

Secondary Outcomes (4)

  • Knee pain

    2 years

  • EQ-5D

    3, 12, 24 months

  • Oxford Knee Score

    3, 12, 24 months

  • Knee Society Score

    3, 12, 24 months

Study Arms (2)

MAKO TKA

EXPERIMENTAL
Device: Triathlon

Conventional

ACTIVE COMPARATOR
Device: Triathlon

Interventions

TriathlonDEVICE

Total knee arthroplasty

ConventionalMAKO TKA

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Listed for elective primary TKR for end stage osteoarthritis
  • Suitable candidate for a cruciate retaining TKR (Triathlon prosthesis)
  • Male or Female, aged 18 years or above (18-80 at the time of listing for surgery).
  • Able to understand and provide written consent.

You may not qualify if:

  • Varus deformity of \> 20 degrees observed by consultant on examination
  • Patient is unable to comply with the study protocol (incl. refusal for CT scan)
  • Female participant who is pregnant, lactating or planning pregnancy during the course of the study.
  • Requires patella resurfacing
  • Inability to understand the patient information for the study, provide written informed consent or answer study questionnaires for cognitive or language reasons
  • Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Sahlgrenska University hospital

Gothenburg, Sweden

RECRUITING

Örebro University Hospital, Department of Medical Sciences

Örebro, 705 85, Sweden

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

October 3, 2022

First Posted

May 6, 2023

Study Start

April 1, 2023

Primary Completion

November 1, 2025

Study Completion (Estimated)

November 1, 2027

Last Updated

October 10, 2023

Record last verified: 2023-10

Data Sharing

IPD Sharing
Will not share

Locations